{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:44:47Z","timestamp":1753883087825,"version":"3.41.2"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Congenital atrioventricular block is a well\u2010established immunologic complication of maternal systemic lupus erythematosus. We sought to further characterize the electrophysiological manifestations of maternal systemic lupus erythematosus on neonatal atria.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Cases of isolated congenital atrioventricular block treated at our center over the past 41\u00a0years were identified. Data were extracted from clinical charts, pacemaker interrogations, ECGs, echocardiograms, and histopathological reports, when available. Of 31 patients with isolated congenital atrioventricular block, 18 were negative for maternal antibodies and had normal epicardial atrial sensing and pacing thresholds. In contrast, 12 of 13 patients with positive maternal antibodies had epicardial pacemakers, 5 (42%) of whom had left atrial (\n              <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n              ) inexcitability and\/or atrial conduction delay. In 3 patients, the\n              <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n              could not be captured despite high\u2010output pacing. The fourth patient had acutely successful\n              <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n              appendage and left ventricular lead placement. At early follow\u2010up, an increased delay between the surface P\u2010wave and intracardiac atrial depolarization was observed, indicative of atrial conduction delay. The fifth patient exhibited\n              <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n              lead dysfunction, with atrial under\u2010sensing and an increased capture threshold, 2\u00a0weeks after implantation. Biopsies of\n              <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n              appendages performed in 2 patients showed no evidence of atrial fibrosis or loss of atrial myocytes.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Herein, we report previously undescribed yet prevalent electrophysiological ramifications of maternal systemic lupus erythematosus, which extend beyond congenital atrioventricular block to encompass alterations in\n              <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n              conduction, including\n              <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n              inexcitability. These manifestations can complicate epicardial pacemaker implantation in newborns. In the absence of histological evidence of extensive atrial fibrosis, immune\u2010mediated functional impairment of electrical activity is suspected.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.115.002676","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T03:53:57Z","timestamp":1450324437000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Left Atrial Inexcitability in Children With Congenital Lupus\u2010Induced Complete Atrioventricular Block"],"prefix":"10.1161","volume":"4","author":[{"given":"Sylvia","family":"Abadir","sequence":"first","affiliation":[{"name":"Divisions of Cardiology and Cardiac Surgery CHU m\u00e8re\u2010enfant Sainte\u2010Justine Universit\u00e9 de Montr\u00e9al Quebec Canada"},{"name":"Department of Cardiology Montreal Children's Hospital McGill University Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Fournier","sequence":"additional","affiliation":[{"name":"Divisions of Cardiology and Cardiac Surgery CHU m\u00e8re\u2010enfant Sainte\u2010Justine Universit\u00e9 de Montr\u00e9al Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne J.","family":"Vobecky","sequence":"additional","affiliation":[{"name":"Divisions of Cardiology and Cardiac Surgery CHU m\u00e8re\u2010enfant Sainte\u2010Justine Universit\u00e9 de Montr\u00e9al Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles V.","family":"Rohlicek","sequence":"additional","affiliation":[{"name":"Department of Cardiology Montreal Children's Hospital McGill University Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Romeo","sequence":"additional","affiliation":[{"name":"Department of Medicine and Pathology Montreal Heart Institute Universit\u00e9 de Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Khairy","sequence":"additional","affiliation":[{"name":"Divisions of Cardiology and Cardiac Surgery CHU m\u00e8re\u2010enfant Sainte\u2010Justine Universit\u00e9 de Montr\u00e9al Quebec Canada"},{"name":"Department of Medicine and Pathology Montreal Heart Institute Universit\u00e9 de Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(64)90248-0"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel308"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(75)90017-X"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780320918"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1191\/096120301673172543"},{"key":"e_1_3_1_7_2","first-page":"234","article-title":"Disorders of conduction in lupus erythematosus: frequency and incidence in a group of 112 patients","volume":"132","author":"Godeau P","year":"1981","unstructured":"Godeau P, Guillevin L, Fechner J, Bletry O, Herreman G. 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