{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:45:40Z","timestamp":1791276340237,"version":"4.1.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,2,23]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">There are limited data describing sex specificities regarding implantable cardioverter defibrillators (ICDs) in the real\u2010world European setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Using a large multicenter cohort of consecutive patients referred for ICD implantation for primary prevention (2002\u20132012), in ischemic and nonischemic cardiomyopathy, we examined the sex differences in subjects' characteristics and outcomes. Of 5539 patients, only 837 (15.1%) were women and 53.8% received cardiac resynchronization therapy. Compared to men, women presented a significantly higher proportion of nonischemic cardiomyopathy (60.2% versus 36.2%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), wider QRS complex width (QRS &gt;120\u00a0ms: 74.6% versus 68.5%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.003), higher New York Heart Association functional class (\u2265III in 54.2%\u2640 versus 47.8%\u2642,\n                      <jats:italic>P<\/jats:italic>\n                      =0.014), and lower prevalence of atrial fibrillation (18.7% versus 24.9%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). During a 16\u00a0786\u00a0patient\u2010years follow\u2010up, overall, fewer appropriate therapies were observed in women (hazard ratio=0.59, 95% CI 0.45\u20130.76;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). By contrast, no sex\u2010specific interaction was observed for inappropriate shocks (odds ratio \u2640=0.84, 95% CI 0.50\u20131.39,\n                      <jats:italic>P<\/jats:italic>\n                      =0.492), early complications (odds ratio=1.00, 95% CI 0.75\u20131.32,\n                      <jats:italic>P<\/jats:italic>\n                      =0.992), and all\u2010cause mortality (hazard ratio=0.87 95% CI 0.66\u20131.15,\n                      <jats:italic>P<\/jats:italic>\n                      =0.324). Analysis of sex\u2010by\u2010 cardiac resynchronization therapy interaction shows than female cardiac resynchronization therapy recipients experienced fewer appropriate therapies than men (hazard ratio=0.62, 95% CI 0.50\u20130.77;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001) and lower mortality (hazard ratio=0.68, 95% CI 0.47\u20130.97;\n                      <jats:italic>P<\/jats:italic>\n                      =0.034).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In our real\u2010life registry, women account for the minority of ICD recipients and presented with a different clinical profile. Whereas female cardiac resynchronization therapy recipients had a lower incidence of appropriate ICD therapies and all\u2010cause death than their male counterparts, the observed rates of inappropriate shocks and early complications in all ICD recipients were comparable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\/\">https:\/\/www.clinicaltrials.gov\/<\/jats:ext-link>\n                      . Unique identifier: NCT01992458.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.115.002756","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T09:11:36Z","timestamp":1536916296000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Primary Prevention Implantable Cardioverter Defibrillator (ICD) Therapy in Women\u2014Data From a Multicenter French Registry"],"prefix":"10.1161","volume":"5","author":[{"given":"Rui","family":"Provid\u00eancia","sequence":"first","affiliation":[{"name":"Clinique Pasteur, Toulouse, France"},{"name":"Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloi","family":"Marijon","sequence":"additional","affiliation":[{"name":"European Georges Pompidou Hospital and Paris Descartes University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier D.","family":"Lambiase","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdeslam","family":"Bouzeman","sequence":"additional","affiliation":[{"name":"Clinique Pasteur, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Defaye","sequence":"additional","affiliation":[{"name":"CHU Michallon, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Klug","sequence":"additional","affiliation":[{"name":"CHRU Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Amet","sequence":"additional","affiliation":[{"name":"European Georges Pompidou Hospital and Paris Descartes University, Paris, 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