{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:04Z","timestamp":1753889824299,"version":"3.41.2"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,6,13]]},"abstract":"\n Background<\/jats:title>\n \n The diagnostic value of the Athens\n QRS<\/jats:styled-content>\n score to detect obstructive coronary artery disease\n CAD<\/jats:styled-content>\n in patients with otherwise normal exercise stress test remains unclear.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We analyzed 458 patients who underwent exercise stress test with or without myocardial perfusion imaging within 2\u00a0months of coronary angiography from 2008 to 2011. Patients (n=173) with abnormal stress test based on\n ST<\/jats:styled-content>\n segment criteria were excluded. The Athens\n QRS<\/jats:styled-content>\n score \u22645 was defined as abnormal. In our study cohort, 285 patients met the inclusion criteria and were divided into 2 groups: low Athens\n QRS<\/jats:styled-content>\n score (\n LQRS<\/jats:styled-content>\n , n=56), with\n QRS<\/jats:styled-content>\n score \u22645 and normal Athens\n QRS<\/jats:styled-content>\n score normal Athens\n QRS<\/jats:styled-content>\n score, n=229), with\n QRS<\/jats:styled-content>\n score >5. The presence of single\u2010vessel and multivessel obstructive\n CAD<\/jats:styled-content>\n was higher in\n LQRS<\/jats:styled-content>\n than in normal Athens\n QRS<\/jats:styled-content>\n score patients (47% versus 7.5% and 30% versus 3.8%, respectively, all\n P<\/jats:italic>\n <0.001). Logistic regression analysis showed that the likelihood of\n CAD<\/jats:styled-content>\n was strongly and independently associated with\n LQRS<\/jats:styled-content>\n (odds ratio=36.81, 95%\n CI<\/jats:styled-content>\n : 10.77\u2013120.47), diabetes (odds ratio=6.49, 95%\n CI<\/jats:styled-content>\n : 2.41\u201317.49), lower maximum heart rate (odds ratio=0.92, 95%\n CI<\/jats:styled-content>\n : 0.88\u20130.95, all\n P<\/jats:italic>\n <0.001), and older age (odds ratio=1.93,\n CI<\/jats:styled-content>\n : 1.88\u20131.97,\n P<\/jats:italic>\n =0.002).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In a clinical cohort of patients with chest pain and normal exercise stress test,\n LQRS<\/jats:styled-content>\n score is a strong independent predictor of presence of\n CAD<\/jats:styled-content>\n .\n LQRS<\/jats:styled-content>\n patients have a 6\u2010fold higher prevalence of\n CAD<\/jats:styled-content>\n and may warrant further evaluation even with reassuring exercise stress test.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.002832","type":"journal-article","created":{"date-parts":[[2016,6,11]],"date-time":"2016-06-11T05:22:33Z","timestamp":1465622553000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Athens QRS Score as a Predictor of Coronary Artery Disease in Patients With Chest Pain and Normal Exercise Stress Test"],"prefix":"10.1161","volume":"5","author":[{"given":"Raza","family":"Alvi","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Bronx\u2010Lebanon Hospital Center, Bronx, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Sklyar","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Bronx\u2010Lebanon Hospital Center, Bronx, NY"},{"name":"Icahn School of Medicine at Mount Sinai, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Gorski","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Bronx\u2010Lebanon Hospital Center, Bronx, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moustapha","family":"Atoui","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Bronx\u2010Lebanon Hospital Center, Bronx, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Afshar","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Bronx\u2010Lebanon Hospital Center, Bronx, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan N.","family":"Bella","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Bronx\u2010Lebanon Hospital Center, Bronx, NY"},{"name":"Icahn School of Medicine at Mount Sinai, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"doi-asserted-by":"publisher","key":"e_1_3_2_2_2","DOI":"10.1161\/01.CIR.57.1.64"},{"doi-asserted-by":"publisher","key":"e_1_3_2_3_2","DOI":"10.1016\/0002-9149(80)90003-X"},{"doi-asserted-by":"publisher","key":"e_1_3_2_4_2","DOI":"10.1161\/01.CIR.65.3.452"},{"doi-asserted-by":"publisher","key":"e_1_3_2_5_2","DOI":"10.1161\/01.CIR.46.5.956"},{"doi-asserted-by":"publisher","key":"e_1_3_2_6_2","DOI":"10.1161\/01.CIR.49.2.348"},{"doi-asserted-by":"publisher","key":"e_1_3_2_7_2","DOI":"10.1016\/S0735-1097(83)80372-6"},{"doi-asserted-by":"publisher","key":"e_1_3_2_8_2","DOI":"10.1161\/01.CIR.80.1.87"},{"key":"e_1_3_2_9_2","first-page":"660","article-title":"Improving diagnostic accuracy of the exercise test by combining R wave changes with duration of ST segment depression in a simplified index","volume":"105","author":"Bermann JA","year":"1983","unstructured":"Bermann JA, Wynne J, Mallis G, Cohn PF. 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