{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:00:17Z","timestamp":1791216017878,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,6,13]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              High\u2010sensitivity troponin (hs\u2010\n              <jats:styled-content style=\"fixed-case\">TNT<\/jats:styled-content>\n              ), a biomarker of myocardial damage, might be useful for assessing fibrosis in Fabry cardiomyopathy. We performed a prospective analysis of hs\u2010\n              <jats:styled-content style=\"fixed-case\">TNT<\/jats:styled-content>\n              as a biomarker for myocardial changes in Fabry patients and a retrospective longitudinal follow\u2010up study to assess longitudinal hs\u2010\n              <jats:styled-content style=\"fixed-case\">TNT<\/jats:styled-content>\n              changes relative to fibrosis and cardiomyopathy progression.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              For the prospective analysis, hs\u2010\n              <jats:styled-content style=\"fixed-case\">TNT<\/jats:styled-content>\n              from 75 consecutive patients with genetically confirmed Fabry disease was analyzed relative to typical Fabry\u2010associated echocardiographic findings and total myocardial fibrosis as measured by late gadolinium enhancement (\n              <jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content>\n              ) on magnetic resonance imaging. Longitudinal data (3.9\u00b12.0\u00a0years), including hs\u2010\n              <jats:styled-content style=\"fixed-case\">TNT<\/jats:styled-content>\n              ,\n              <jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content>\n              , and echocardiographic findings from 58 Fabry patients, were retrospectively collected. Hs\u2010\n              <jats:styled-content style=\"fixed-case\">TNT<\/jats:styled-content>\n              level positively correlated with\n              <jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content>\n              (linear correlation coefficient, 0.72; odds ratio, 32.81 [95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              3.56\u2013302.59];\n              <jats:italic>P<\/jats:italic>\n              =0.002); patients with elevated baseline hs\u2010\n              <jats:styled-content style=\"fixed-case\">TNT<\/jats:styled-content>\n              (&gt;14\u00a0ng\/L) showed significantly increased\n              <jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content>\n              (median: baseline, 1.9 [1.1\u20133.3] %; follow\u2010up, 3.2 [2.3\u20134.9] %;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and slightly elevated hs\u2010\n              <jats:styled-content style=\"fixed-case\">TNT<\/jats:styled-content>\n              (baseline, 44.7 [30.1\u201365.3] ng\/L; follow\u2010up, 49.1 [27.6\u201369.5] ng\/L;\n              <jats:italic>P<\/jats:italic>\n              =0.116) during follow\u2010up. Left ventricular wall thickness and\n              <jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>\n              of patients with elevated hs\u2010\n              <jats:styled-content style=\"fixed-case\">TNT<\/jats:styled-content>\n              were decreased during follow\u2010up, indicating potential cardiomyopathy progression.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              hs\u2010\n              <jats:styled-content style=\"fixed-case\">TNT<\/jats:styled-content>\n              is an accurate, easily accessible clinical blood biomarker for detecting replacement fibrosis in patients with Fabry disease and a qualified predictor of cardiomyopathy progression. Thus, hs\u2010\n              <jats:styled-content style=\"fixed-case\">TNT<\/jats:styled-content>\n              could be helpful for staging and follow\u2010up of Fabry patients.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.115.002839","type":"journal-article","created":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T03:09:23Z","timestamp":1464750563000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":63,"title":["High\u2010Sensitivity Troponin: A Clinical Blood Biomarker for Staging Cardiomyopathy in Fabry Disease"],"prefix":"10.1161","volume":"5","author":[{"given":"Nora","family":"Seydelmann","sequence":"first","affiliation":[{"name":"Medizinische Klinik I, University Hospital W\u00fcrzburg, and Comprehensive Heart Failure Center, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, University Hospital W\u00fcrzburg, and Comprehensive Heart Failure Center, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kr\u00e4mer","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, University Hospital W\u00fcrzburg, and Comprehensive Heart Failure Center, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Drechsler","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, University Hospital W\u00fcrzburg, and Comprehensive Heart Failure Center, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Hu","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, University Hospital W\u00fcrzburg, and Comprehensive Heart Failure Center, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Nordbeck","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, University Hospital W\u00fcrzburg, and Comprehensive Heart Failure Center, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schneider","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, University Hospital W\u00fcrzburg, and Comprehensive Heart Failure Center, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"St\u00f6rk","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, University Hospital W\u00fcrzburg, and Comprehensive Heart Failure Center, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Bijnens","sequence":"additional","affiliation":[{"name":"ICREA\u2013Universitat Pompeu Fabra, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Ertl","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, University Hospital W\u00fcrzburg, and Comprehensive Heart Failure Center, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Wanner","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, University Hospital W\u00fcrzburg, and Comprehensive Heart Failure Center, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Weidemann","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, University Hospital W\u00fcrzburg, and Comprehensive Heart Failure Center, W\u00fcrzburg, Germany"},{"name":"Innere Klinik II, Katharinen\u2010Hospital, Unna, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-4-200302180-00014"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.01.035"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2013.02.003"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.11.750"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi143"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2003.09.017"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm153"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000209649.60409.38"},{"key":"e_1_3_3_10_2","first-page":"38","article-title":"Cardiac abnormalities in Anderson\u2010Fabry disease and Fabry's cardiomyopathy","volume":"22","author":"Morrissey RP","year":"2011","unstructured":"Morrissey RP, Philip KJ, Schwarz ER. 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