{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:14:24Z","timestamp":1793862864620,"version":"4.6.1"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,6,13]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Estimates of long\u2010term survival are required to adequately assess the variety of health and social services required by those with congenital heart disease (\n              <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>\n              ) throughout their lives.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Medline, Embase, and Scopus were searched from inception to June 2015 using Me\n              <jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>\n              headings and keywords. Population\u2010based studies that ascertained all persons born with\n              <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>\n              within a predefined area and reported survival estimates at \u22655\u00a0years were included. Unadjusted survival estimates for each\n              <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>\n              subtype at ages 1 year, 5 years, 10 years, and so forth were extracted. Pooled survival estimates for each age were calculated using meta\u2010analyses. Metaregression was performed to examine the impact of study period on survival. Of 7840 identified articles, 16 met the inclusion criteria. Among those with\n              <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>\n              , pooled 1\u2010year survival was 87.0% (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              82.1\u201391.2), pooled 5\u2010year survival was 85.4% (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              79.4\u201390.5), and pooled 10\u2010year survival was 81.4% (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              73.8\u201387.9). There was significant heterogeneity of survival estimates among articles (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 for 1\u2010, 5\u2010, and 10\u2010year survival). A more recent study period was significantly associated with greater survival at ages 1 year (\n              <jats:italic>P<\/jats:italic>\n              =0.047), 5 years (\n              <jats:italic>P<\/jats:italic>\n              =0.013), and 10 years (\n              <jats:italic>P<\/jats:italic>\n              =0.046). Survival varied by\n              <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>\n              subtype, with 5\u2010year survival being greatest for those with ventricular septal defect (96.3%, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              93.7\u201398.2) and lowest for those with hypoplastic left heart (12.5%, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.0\u201341.4).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Among persons with\n              <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>\n              , the mortality rate is greatest during the first year of life; however, this systematic review and meta\u2010analysis showed that survival decreases gradually after infancy and into adulthood.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.115.002846","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T02:49:41Z","timestamp":1466131781000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":137,"title":["Long\u2010Term Survival of Individuals Born With Congenital Heart Disease: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1161","volume":"5","author":[{"given":"Kate E.","family":"Best","sequence":"first","affiliation":[{"name":"Institute of Health &amp; Society, Newcastle University, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Rankin","sequence":"additional","affiliation":[{"name":"Institute of Health &amp; Society, Newcastle University, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.05.059"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.958405"},{"key":"e_1_3_4_5_2","first-page":"1208","article-title":"Racial differences by gestational age in neonatal deaths attributable to congenital heart defects\u2014United States, 2003\u20132006","volume":"59","author":"Centers for Disease Control Prevention","year":"2010","unstructured":"Centers for Disease Control Prevention . 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