{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:34:24Z","timestamp":1791275664799,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,1,13]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Exosomes derived from mesenchymal stem cells (\n              <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n              s) were proved to boost cell proliferation and angiogenic potency. We explored whether cardiac stem cells (CSCs) preconditioned with\n              <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n              exosomes could survive and function better in a myocardial infarction model.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              DiI\u2010labeled exosomes were internalized with\n              <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>\n              s. They stimulated proliferation, migration, and angiotube formation of\n              <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>\n              s in a dose\u2010dependent manner. In a rat myocardial infarction model,\n              <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n              exosome\u2013preconditioned\n              <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>\n              s had significantly better survival, enhanced capillary density, reduced cardiac fibrosis, and restored long\u2010term cardiac function. Micro\n              <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n              profiling analysis revealed that a set of micro\n              <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n              s were significantly changed in\n              <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>\n              s after\n              <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n              exosome treatment.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Pretreatment of CSCs with\n              <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n              exosomes provided a promising strategy to improve survival and angiogenic potency of CSCs.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.115.002856","type":"journal-article","created":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T03:48:13Z","timestamp":1453780093000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":194,"title":["Pretreatment of Cardiac Stem Cells With Exosomes Derived From Mesenchymal Stem Cells Enhances Myocardial Repair"],"prefix":"10.1161","volume":"5","author":[{"given":"Zhiwei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery of The First Affiliated Hospital &amp; Institute for Cardiovascular Science, Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery of The First Affiliated Hospital &amp; Institute for Cardiovascular Science, Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiya","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery of The First Affiliated Hospital &amp; Institute for Cardiovascular Science, Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangxin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery of The First Affiliated Hospital &amp; Institute for Cardiovascular Science, Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenya","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery of The First Affiliated Hospital &amp; 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