{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:33:25Z","timestamp":1790429605846,"version":"4.1.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,2,23]]},"abstract":"\n Background<\/jats:title>\n \n The aim of this study was to compare left ventricular (\n LV<\/jats:styled-content>\n ) remodeling using myocardial strain between patients with severe aortic stenosis (\n AS<\/jats:styled-content>\n ) treated with transcatheter aortic valve replacement (\n TAVR<\/jats:styled-content>\n ) with and without prosthesis\u2010patient mismatch (\n PPM<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n In a retrospective study, speckle\u2010tracking echocardiography was used to measure global longitudinal strain (\n GLS<\/jats:styled-content>\n ) and strain rate (\n GLSR<\/jats:styled-content>\n ), circumferential strain, and rotation before and at mid\u2010term follow\u2010up post\u2010\n TAVR<\/jats:styled-content>\n . Moderate and severe\n PPM<\/jats:styled-content>\n were defined as an effective orifice area \u22640.85 and <0.65\u00a0cm\n 2<\/jats:sup>\n \/m\n 2<\/jats:sup>\n , respectively. A total of 102 patients (median age, 83\u00a0years [77\u201388]) with severe\n AS<\/jats:styled-content>\n were included. At 6\u00b13\u00a0months post\u2010\n TAVR<\/jats:styled-content>\n , moderate and severe\n PPM<\/jats:styled-content>\n were found in 32 (31%) and 9 (9%) patients. Patients without\n PPM<\/jats:styled-content>\n had a significant regression in\n LV<\/jats:styled-content>\n mass (from 134\u00b141 to 119\u00b138\u00a0g\/m\n 2<\/jats:sup>\n ;\n P<\/jats:italic>\n =0.001) at follow\u2010up whereas those with\n PPM<\/jats:styled-content>\n did not. There was a significant improvement in\n LV GLS<\/jats:styled-content>\n (\u221212.8\u00b14.0 to \u221214.3\u00b14.3%;\n P<\/jats:italic>\n =0.01),\n GLSR<\/jats:styled-content>\n (\u22120.61\u00b10.20 to \u22120.73\u00b10.25\u00a0second\n \u22121<\/jats:sup>\n ;\n P<\/jats:italic>\n <0.001), and early diastolic strain rate (0.52\u00b10.20 to 0.64\u00b10.20\u00a0second\n \u22121<\/jats:sup>\n ;\n P<\/jats:italic>\n <0.001) in patients without\n PPM<\/jats:styled-content>\n , but not in those with\n PPM<\/jats:styled-content>\n . After adjustment for pre\u2010\n TAVR<\/jats:styled-content>\n ejection fraction and post\u2010\n TAVR<\/jats:styled-content>\n aortic regurgitation, patients without\n PPM<\/jats:styled-content>\n had greater improvement in\n LV<\/jats:styled-content>\n longitudinal strain parameters compared to those with\n PPM<\/jats:styled-content>\n . After a median follow\u2010up of 46.1\u00a0months (interquartile range, 35.4\u201360.8), there was no difference in survival between patients with and without\n PPM<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n TAVR<\/jats:styled-content>\n was associated with an incidence of\n PPM<\/jats:styled-content>\n of 40%. Greater reverse\n LV<\/jats:styled-content>\n remodeling using myocardial strain was evident in patients without\n PPM<\/jats:styled-content>\n compared to\n PPM<\/jats:styled-content>\n . Presence of\n PPM<\/jats:styled-content>\n was not associated with mortality.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.002866","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T23:17:15Z","timestamp":1454973435000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["Impact of Prosthesis\u2010Patient Mismatch on Left Ventricular Myocardial Mechanics After Transcatheter Aortic Valve Replacement"],"prefix":"10.1161","volume":"5","author":[{"given":"Fr\u00e9d\u00e9ric","family":"Poulin","sequence":"first","affiliation":[{"name":"Peter Munk Cardiac Center, Toronto General Hospital, University of Toronto Toronto Ontario, Canada"},{"name":"Research Center, H\u00f4pital du Sacr\u00e9\u2010Coeur de Montr\u00e9al, University of Montreal Montreal Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teerapat","family":"Yingchoncharoen","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Foundation, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Peter Munk Cardiac Center, Toronto General Hospital, University of Toronto Toronto Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Horlick","sequence":"additional","affiliation":[{"name":"Peter Munk Cardiac Center, Toronto General Hospital, University of Toronto Toronto Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"G\u00e9n\u00e9reux","sequence":"additional","affiliation":[{"name":"Research Center, H\u00f4pital du Sacr\u00e9\u2010Coeur de Montr\u00e9al, University of Montreal Montreal Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Murat","family":"Tuzcu","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Foundation, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Stewart","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Foundation, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Osten","sequence":"additional","affiliation":[{"name":"Peter Munk Cardiac Center, Toronto General Hospital, University of Toronto Toronto Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Woo","sequence":"additional","affiliation":[{"name":"Peter Munk Cardiac Center, Toronto General Hospital, University of Toronto Toronto Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paaladinesh","family":"Thavendiranathan","sequence":"additional","affiliation":[{"name":"Peter Munk Cardiac Center, Toronto General Hospital, University of Toronto Toronto Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200384"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.01.060"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.087"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.04.015"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.06.1195"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-011-0172-7"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.01.015"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.12.006"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.07.001"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.04.023"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.04.021"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.11.029"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(03)00335-3"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.06.021"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.09.001"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.029"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.02.006"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.05.026"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.001681"},{"key":"e_1_3_3_22_2","first-page":"309","article-title":"Incidence and impact of prosthesis\u2010patient mismatch after transcatheter aortic valve implantation","volume":"22","author":"Bleiziffer S","year":"2013","unstructured":"Bleiziffer S, Hettich I, Hutter A, Wagner A, Deutsch MA, Piazza N, Lange R. Incidence and impact of prosthesis\u2010patient mismatch after transcatheter aortic valve implantation. J Heart Valve Dis. 2013;22:309\u2013316.","journal-title":"J Heart Valve Dis"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.027"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp537"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1311534"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.036"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-014-0510-0"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.08.027"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.09.022"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.07.003"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002677"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.075"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.115.002866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T06:26:48Z","timestamp":1715581608000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.115.002866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,23]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2,23]]}},"alternative-id":["10.1161\/JAHA.115.002866"],"URL":"https:\/\/doi.org\/10.1161\/jaha.115.002866","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,23]]},"assertion":[{"value":"2015-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e002866"}}