{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:43:00Z","timestamp":1791243780151,"version":"4.1.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,4,3]]},"abstract":"\n Background<\/jats:title>\n \n The cardiovascular effects of positive airway pressure (\n PAP<\/jats:styled-content>\n ) therapy in obstructive sleep apnea (\n OSA<\/jats:styled-content>\n ) patients are not clear because of confounding by comorbid conditions.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Prospective interventional study of\n PAP<\/jats:styled-content>\n therapy and withdrawal. Apnea Hypopnea Index (\n AHI<\/jats:styled-content>\n ; events\/hour of sleep) was determined from polysomnography. Central aortic blood pressures (\n BPs<\/jats:styled-content>\n ), Aortic Augmentation Index (\n AAI<\/jats:styled-content>\n x), and central (\n PWV<\/jats:styled-content>\n c\u2010f<\/jats:sub>\n ) and peripheral pulse wave (\n PWV<\/jats:styled-content>\n c\u2010r<\/jats:sub>\n ) velocities were determined by applanation tonometry. Echocardiography and brachial artery reactivity testing were performed at baseline, after 4 and 12\u00a0weeks of\n PAP<\/jats:styled-content>\n therapy, and 1\u00a0week after\n PAP<\/jats:styled-content>\n withdrawal. The 84 participants were mean (SD) 41.1 (7.6) years old and had 39.8 (24.5)\n AHI<\/jats:styled-content>\n events\/hour. After 4\u00a0weeks post\u2010\n PAP<\/jats:styled-content>\n initiation and sustained after 12\u00a0weeks, subjects experienced decreases in central systolic\n BP<\/jats:styled-content>\n (\n P<\/jats:italic>\n =0.008), diastolic\n BP<\/jats:styled-content>\n , mean\n BP<\/jats:styled-content>\n ,\n AAI<\/jats:styled-content>\n x, and\n PWV<\/jats:styled-content>\n c\u2010r<\/jats:sub>\n , and brachial artery dilation (all\n P<\/jats:italic>\n <0.001), as well as improvements in left ventricular diastolic function and systemic and pulmonary vascular resistance. In adjusted models,\n PAP<\/jats:styled-content>\n use (hours\/night) predicted reductions in diastolic\n BP<\/jats:styled-content>\n (\u03b2=\u22120.65 [SE, 0.32] mm\u00a0Hg\/hour;\n P<\/jats:italic>\n =0.045),\n AAI<\/jats:styled-content>\n x (\u03b2=\u22120.53 [0.27] %\/hour;\n P<\/jats:italic>\n =0.049) and\n PWV<\/jats:styled-content>\n c\u2010r<\/jats:sub>\n (\u03b2=\u22120.13 [0.05] m\u00b7s\n \u22121<\/jats:sup>\n \/hour;\n P<\/jats:italic>\n =0.007), and improved brachial artery flow\u2010mediated dilation (\u03b2=0.31 [0.14] %\/hour use;\n P<\/jats:italic>\n =0.015). After 1\u00a0week of\n PAP<\/jats:styled-content>\n withdrawal, brachial diameter, diastolic\n BP<\/jats:styled-content>\n , mean\n BP<\/jats:styled-content>\n ,\n AAI<\/jats:styled-content>\n x, and heart rate increased (\n P<\/jats:italic>\n \u22640.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n PAP<\/jats:styled-content>\n therapy reduces arterial tone and improves endothelial and diastolic function in young to middle\u2010aged adults. This positive effect is observed after 4\u00a0weeks and depends on hours of use, but reverts quickly with\n PAP<\/jats:styled-content>\n withdrawal.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL:\n https:\/\/clinicaltrials.gov\/<\/jats:ext-link>\n . Unique identifier:\n NCT<\/jats:styled-content>\n 01317329.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.002930","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T12:25:31Z","timestamp":1536927931000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Treatment of Obstructive Sleep Apnea in Young and Middle\u2010Aged Adults: Effects of Positive Airway Pressure and Compliance on Arterial Stiffness, Endothelial Function, and Cardiac Hemodynamics"],"prefix":"10.1161","volume":"5","author":[{"given":"Claudia E.","family":"Korcarz","sequence":"first","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Benca","sequence":"additional","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi H.","family":"Barnet","sequence":"additional","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Stein","sequence":"additional","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws342"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0375"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4086"},{"key":"e_1_3_4_5_2","first-page":"263","article-title":"Sleep disordered breathing and metabolic syndrome","volume":"108","author":"Nieto FJ","year":"2009","unstructured":"Nieto FJ, Peppard PE, Young TB. 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