{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:51:34Z","timestamp":1762102294249,"version":"3.41.2"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,5,6]]},"abstract":"\n Background<\/jats:title>\n \n Inflammation of the aortic wall is recognised as a key pathogenesis of abdominal aortic aneurysm (\n AAA<\/jats:styled-content>\n ). This study was undertaken to determine whether inflammatory cytokines could be used as biomarkers for the presence of\n AAA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Tissue profiles of 27 inflammatory cytokine were examined in\n AAA<\/jats:styled-content>\n (n=14) and nonaneurysmal (n=14) aortic tissues. Three cytokines, regulated upon activation normally T\u2010cell expressed and secreted (\n RANTES<\/jats:styled-content>\n ), eotaxin, and macrophage inflammatory protein 1 beta (\n MIP\u2010<\/jats:styled-content>\n 1b), had increased expression in\n AAA<\/jats:styled-content>\n , particularly within the adventitial layer of the aortic wall. Basic fibroblast growth factor (\n bFGF<\/jats:styled-content>\n ) had reduced expression in all layers of the\n AAA<\/jats:styled-content>\n wall. Examination of the circulating plasma profiles of\n AAA<\/jats:styled-content>\n (n=442) and\n AAA<\/jats:styled-content>\n \u2010free controls (n=970) suggested a (risk factor adjusted)\n AAA<\/jats:styled-content>\n \u2010association with eotaxin,\n RANTES<\/jats:styled-content>\n , and high sensitivity C\u2010reactive protein (hs\n CRP<\/jats:styled-content>\n ). A plasma inflammatory cytokine score, calculated using these three markers, suggested a strong risk association with\n AAA<\/jats:styled-content>\n (odds ratio, 4.8; 95%\n CI<\/jats:styled-content>\n , 3.5\u20136.7;\n P<\/jats:italic>\n <0.0001), independent of age, sex, history of ischemic heart disease, and smoking.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Contrary to reports suggesting a distinct T helper 2\u2013associated inflammatory profile in\n AAA<\/jats:styled-content>\n , this current study suggests a more\u2010generalized pattern of inflammation, albeit with some potentially distinct features, including elevated plasma eotaxin and decreased plasma\n RANTES<\/jats:styled-content>\n . In combination with hs\n CRP<\/jats:styled-content>\n , these markers may have potential utility as\n AAA<\/jats:styled-content>\n biomarkers.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.002993","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T12:21:10Z","timestamp":1536927670000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Two C\u2010C Family Chemokines, Eotaxin and RANTES, Are Novel Independent Plasma Biomarkers for Abdominal Aortic Aneurysm"],"prefix":"10.1161","volume":"5","author":[{"given":"Gregory T.","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Otago, Dunedin, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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