{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:37:03Z","timestamp":1789439823792,"version":"build-2803163510"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,2,23]]},"abstract":"\n Background<\/jats:title>\n \n Studies have suggested that patients with atrial fibrillation (\n AF<\/jats:styled-content>\n ) have impairment in the baroreflex. It is not clear whether these findings are the result of the associated comorbid conditions or the arrhythmia itself. We hypothesized that\n AF<\/jats:styled-content>\n is associated with impairment in baroreflex function and that the arrhythmia itself is a contributing factor.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Twenty\u2010four patients with persistent\n AF<\/jats:styled-content>\n referred for cardioversion were enrolled. A second group of patients with no history of\n AF<\/jats:styled-content>\n matched for age and left ventricular ejection fraction was identified and served as the control group. In the\n AF<\/jats:styled-content>\n group, baroreflex gain (\n BRG<\/jats:styled-content>\n ) was measured on the day of cardioversion (Day 1) and again at 30\u00a0days post\u2010cardioversion (Day 30) in patients who remained in sinus rhythm (\n SR<\/jats:styled-content>\n ). The clinical characteristics of patients with\n AF<\/jats:styled-content>\n were not different than those of the control group. The mean\n BRG<\/jats:styled-content>\n in the\n AF<\/jats:styled-content>\n group on Day 1 was significantly lower than the mean\n BRG<\/jats:styled-content>\n of the control group (5.2\u00b13.6\u00a0versus 10.8\u00b15.5\u00a0ms\/mm\u00a0Hg,\n P<\/jats:italic>\n <0.05). Ten patients experienced\n AF<\/jats:styled-content>\n recurrence before the 30\u2010day follow\u2010up and 14 patients remained in\n SR<\/jats:styled-content>\n . In the group that remained in\n SR<\/jats:styled-content>\n ,\n BRG<\/jats:styled-content>\n increased from 4.1\u00b13.7 ms\/mm Hg on Day 1 to 7.0\u00b16.0\u00a0ms\/mm\u00a0Hg on Day 30 (\n P<\/jats:italic>\n <0.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n We have shown that\n AF<\/jats:styled-content>\n is associated with impairment of the baroreflex and that restoration of\n SR<\/jats:styled-content>\n improves\n BRG<\/jats:styled-content>\n . Our data suggest that\n AF<\/jats:styled-content>\n might be a contributing factor to the observed impairment in\n BRG<\/jats:styled-content>\n and that restoring\n SR<\/jats:styled-content>\n might help improve baroreflex function.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.002997","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T04:38:50Z","timestamp":1456288730000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Restoring Sinus Rhythm Improves Baroreflex Function in Patients With Persistent Atrial Fibrillation"],"prefix":"10.1161","volume":"5","author":[{"given":"Michael E.","family":"Field","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Wasmund","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Page","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed H.","family":"Hamdan","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.08.108"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2006.00362.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1998.tb00062.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000064900.76674.CC"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.6.1362"},{"key":"e_1_3_3_7_2","first-page":"S79","article-title":"A new approach to analysis of the arterial baroreflex","volume":"3","author":"Bertinieri G","year":"1985","unstructured":"Bertinieri G, di Rienzo M, Cavallazzi A, Ferrari AU, Pedotti A, Mancia G. 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