{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:03:53Z","timestamp":1783782233121,"version":"3.55.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,6,13]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010segment elevation myocardial infarction is increasingly common in octogenarians, and optimal management in this cohort is uncertain. This study aimed to describe the outcomes of octogenarians with\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010segment elevation myocardial infarction treated by primary percutaneous coronary intervention.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We analyzed 10 249 consecutive patients with\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010segment elevation myocardial infarction treated with primary percutaneous coronary intervention between 2005 and 2011 at 8 tertiary cardiac centers across London, United Kingdom. The primary end point was all\u2010cause mortality at a median follow\u2010up of 3\u00a0years. In total, 1051 patients (10.3%) were octogenarians, with an average age of 84.2\u00a0years, and the proportion increased over the study period (\n              <jats:italic>P<\/jats:italic>\n              =0.04). In\u2010hospital mortality (7.7% vs 2.4%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) and long\u2010term mortality (51.6% vs 12.8%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) were increased in octogenarians compared with patients aged &lt;80\u00a0years, and age was an independent predictor of mortality in a fully adjusted model (hazard ratio 1.07, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.07\u20131.09,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). Time\u2010stratified analysis revealed an increasingly elderly and more complex cohort over time. Nonetheless, long\u2010term mortality rates among octogenarians remained static over time, and this may be attributable to improved percutaneous coronary intervention techniques, including significantly higher rates of radial access and lower bleeding complications. Variables associated with bleeding complications were similar between octogenarian and younger cohorts.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In this large registry, octogenarians undergoing primary percutaneous coronary intervention had a higher rate of complications and mortality compared with a younger population. Over time, octogenarians undergoing primary percutaneous coronary intervention increased in number, age, and complexity. Nevertheless, in\u2010hospital outcomes were reasonable, and long\u2010term mortality rates were static.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.115.003027","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T17:54:51Z","timestamp":1467222891000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Outcome of 1051 Octogenarian Patients With ST\u2010Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention: Observational Cohort From the London Heart Attack Group"],"prefix":"10.1161","volume":"5","author":[{"given":"Daniel I.","family":"Bromage","sequence":"first","affiliation":[{"name":"The Hatter Cardiovascular Institute, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Jones","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust, St Bartholomew's Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnaraj S.","family":"Rathod","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust, St Bartholomew's Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Grout","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust, St Bartholomew's Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Bilal","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Royal Brompton &amp; Harefield NHS Foundation Trust, Harefield Hospital, Middlesex, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pitt","family":"Lim","sequence":"additional","affiliation":[{"name":"St. George's Healthcare NHS Foundation Trust, St. George's Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Jain","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust, St Bartholomew's Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundeep S.","family":"Kalra","sequence":"additional","affiliation":[{"name":"Kings College Hospital, King's College Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Crake","sequence":"additional","affiliation":[{"name":"UCL Hospitals NHS Foundation Trust, Heart Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Astroulakis","sequence":"additional","affiliation":[{"name":"St. George's Healthcare NHS Foundation Trust, St. George's Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mick","family":"Ozkor","sequence":"additional","affiliation":[{"name":"UCL Hospitals NHS Foundation Trust, Heart Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roby D.","family":"Rakhit","sequence":"additional","affiliation":[{"name":"Royal Free London NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J.","family":"Knight","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust, St Bartholomew's Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles C.","family":"Dalby","sequence":"additional","affiliation":[{"name":"Royal Brompton &amp; Harefield NHS Foundation Trust, Harefield Hospital, Middlesex, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqbal S.","family":"Malik","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Foundation Trust, Hammersmith Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Mathur","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust, St Bartholomew's Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Redwood","sequence":"additional","affiliation":[{"name":"BHF Centre of Excellence, King's College London, St. Thomas Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"MacCarthy","sequence":"additional","affiliation":[{"name":"Kings College Hospital, King's College Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wragg","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust, St Bartholomew's Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07963.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.04.227"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1076-7460.2006.05273.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.01.012"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.108.826172"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.05.006"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.185678"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.24591"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12113-7"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199303113281001"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025142"},{"key":"e_1_3_3_13_2","first-page":"474","article-title":"Treatment and outcomes of nonagenarians with ST\u2010elevation myocardial infarction","volume":"22","author":"Ionescu CN","year":"2010","unstructured":"Ionescu CN, Amuchastegui M, Ionescu S, Marcu CB, Donohue T. Treatment and outcomes of nonagenarians with ST\u2010elevation myocardial infarction. J Invasive Cardiol. 2010;22:474\u2013478.","journal-title":"J Invasive Cardiol"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.08.051"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22810"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-305445"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.06.026"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.03.046"},{"key":"e_1_3_3_19_2","first-page":"27","article-title":"Percutaneous coronary intervention in the very elderly (>85\u00a0years): trends and outcomes","volume":"20","author":"Rana O","year":"2013","unstructured":"Rana O, Moran R, O'Kane P, Boyd S, Swallow R, Talwar S, Levy T. Percutaneous coronary intervention in the very elderly (>85\u00a0years): trends and outcomes. Br J Cardiol. 2013;20:27\u201331.","journal-title":"Br J Cardiol"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/2048872615574706"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs215"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182742c84"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300299"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.01.013"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.03.045"},{"key":"e_1_3_3_26_2","first-page":"114","article-title":"One\u2010year clinical outcome of elderly patients undergoing angioplasty for st\u2010elevation myocardial infarction complicated by cardiogenic shock: the importance of 3\u2010vessel disease and final timi\u20103 flow grade","volume":"26","author":"De Felice F","year":"2014","unstructured":"De Felice F, Guerra E, Fiorilli R, Parma A, Musto C, Nazzaro MS, Violini R. One\u2010year clinical outcome of elderly patients undergoing angioplasty for st\u2010elevation myocardial infarction complicated by cardiogenic shock: the importance of 3\u2010vessel disease and final timi\u20103 flow grade. J Invasive Cardiol. 2014;26:114\u2013118.","journal-title":"J Invasive Cardiol"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00972-X"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02120-8"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(09)60184-4"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00150-2"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708191"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60833-8"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1308789"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv176"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)06113-3"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000087601.45803.86"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.818617"},{"key":"e_1_3_3_38_2","first-page":"404","article-title":"Drug\u2010eluting stents in the elderly: long\u2010term (> one year) clinical outcomes of octogenarians in the DESIRE (Drug\u2010Eluting Stents in the REal world) registry","volume":"20","author":"Costa JR","year":"2008","unstructured":"Costa JR Jr, Sousa A, Moreira AC, Costa RA, Maldonado G, Cano MN, Egito ET, Romano ER, Barbosa M, Pavanello R, Jardim C, Cury A, Berwanger O, Sousa JE. Drug\u2010eluting stents in the elderly: long\u2010term (> one year) clinical outcomes of octogenarians in the DESIRE (Drug\u2010Eluting Stents in the REal world) registry. J Invasive Cardiol.. 2008;20:404\u2013410.","journal-title":"J Invasive Cardiol."},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(12)61527-7"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2009.04.107"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(03)00079-6"},{"key":"e_1_3_3_42_2","first-page":"170","article-title":"Radial primary percutaneous coronary intervention is independently associated with decreased long\u2010term mortality in high\u2010risk st\u2010elevation myocardial infarction patients","volume":"16","author":"Rathod KS","year":"2015","unstructured":"Rathod KS, Jones DA, Bromage DI, Gallagher SM, Rathod VS, Kennon S, Knight C, Rothman MT, Mathur A, Smith E, Jain AK, Archbold RA, Wragg A. Radial primary percutaneous coronary intervention is independently associated with decreased long\u2010term mortality in high\u2010risk st\u2010elevation myocardial infarction patients. J\u00a0Cardiovasc Med (Hagerstown). 2015;16:170\u2013177.","journal-title":"J\u00a0Cardiovasc Med (Hagerstown)"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.612812"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp499"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X30725"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.04.016"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20354"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.191916"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.115.003027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:51:45Z","timestamp":1715597505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.115.003027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,13]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6,13]]}},"alternative-id":["10.1161\/JAHA.115.003027"],"URL":"https:\/\/doi.org\/10.1161\/jaha.115.003027","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,13]]},"assertion":[{"value":"2016-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e003027"}}