{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:33:24Z","timestamp":1790199204214,"version":"4.1.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,3,9]]},"abstract":"\n Background<\/jats:title>\n Hypertension is one of the main comorbidities associated with dyslipidemia. This study aimed to examine the extent to which dyslipidemia increases the risk of developing hypertension in a Japanese working\u2010age male population.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We analyzed data from 14\u00a0215 nonhypertensive male workers (age 38\u00b19\u00a0years) who underwent annual medical checkups. Subjects were followed up for a median of 4\u00a0years to determine new\u2010onset hypertension, defined as blood pressure (\n BP<\/jats:styled-content>\n ) \u2265140\/90\u00a0mm\u00a0Hg or use of antihypertensive medication. The associations between serum lipid levels and development of hypertension were examined. During the follow\u2010up period, 1483 subjects developed hypertension. After adjusting for age, body mass index, impaired fasting glucose\/diabetes, baseline\n BP<\/jats:styled-content>\n category, alcohol intake, smoking, exercise, and parental history of hypertension, subjects with a total cholesterol (\n TC<\/jats:styled-content>\n ) level \u2265222\u00a0mg\/dL were at a significantly increased risk of developing hypertension (hazard ratio: 1.28; 95%\n CI<\/jats:styled-content>\n : 1.06\u20131.56) compared to subjects with a\n TC<\/jats:styled-content>\n level \u2264167\u00a0mg\/dL. Similar results were observed for subjects with high low\u2010density lipoprotein cholesterol (\n LDLC<\/jats:styled-content>\n ) and non\u2010high\u2010density lipoprotein cholesterol (\n HDLC<\/jats:styled-content>\n ) levels. A U\u2010shaped relationship was found between\n HDLC<\/jats:styled-content>\n level and risk of hypertension; compared to the third quintile, the multiadjusted hazard ratio was 1.22 (95%\n CI<\/jats:styled-content>\n : 1.03\u20131.43) in the lowest quintile and 1.34 (95%\n CI<\/jats:styled-content>\n : 1.12\u20131.60) in the highest quintile.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Elevated serum levels of\n TC<\/jats:styled-content>\n ,\n LDLC<\/jats:styled-content>\n , and non\u2010\n HDLC<\/jats:styled-content>\n were associated with an increased risk of hypertension in working\u2010age Japanese men. For\n HDLC<\/jats:styled-content>\n , risk of hypertension was increased at both low and high levels.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.003053","type":"journal-article","created":{"date-parts":[[2016,3,25]],"date-time":"2016-03-25T21:08:38Z","timestamp":1458940118000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":161,"title":["Dyslipidemia and the Risk of Developing Hypertension in a Working\u2010Age Male Population"],"prefix":"10.1161","volume":"5","author":[{"given":"Toshiaki","family":"Otsuka","sequence":"first","affiliation":[{"name":"Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Takada","sequence":"additional","affiliation":[{"name":"Industrial Safety and Health Center, Canon Inc., Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nippon Medical School Musashi Kosugi Hospital, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eitaro","family":"Kodani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Nippon Medical School Tama Nagayama Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Saiki","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhito","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Kawada","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69472-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60527-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199511163332001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04262"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38855.610324.80"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000151745.67285.c2"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.621"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.01.024"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2008.00065.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.6.2541"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114688"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01723-0"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200402000-00009"},{"key":"e_1_3_2_15_2","first-page":"554","article-title":"A prospective study on the association between dyslipidemia and hypertension","volume":"30","author":"Guo ZR","year":"2009","unstructured":"Guo ZR, Hu XS, Wu M, Zhou MH, Zhou ZY. 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