{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:23:21Z","timestamp":1768278201074,"version":"3.49.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,8,8]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Rehospitalizations following acute myocardial infarction for unplanned coronary revascularization and unstable angina (\n              <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>\n              ) are often included as parts of composite end points in clinical trials. Although clearly costly, the clinical relevance of these individual components has not been described.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Patients enrolled in a prospective, 24\u2010center, US acute myocardial infarction registry were followed for 1\u00a0year after an acute myocardial infarction for rehospitalizations, that were independently adjudicated by experienced cardiologists. Patients who did and did not experience\n              <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>\n              or revascularization rehospitalization were propensity matched using greedy matching. Among 3283 patients with acute myocardial infarction who were included, mean age was 59\u00a0years, 33% were female, and 70% were white. Rehospitalization rates for\n              <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>\n              and unplanned revascularization at 1\u00a0year were 5.0% and 4.1%, respectively. After propensity matching, we included 2433 patients in the\n              <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>\n              rehospitalization group and 2410 in the unplanned revascularization group. Using weighted proportional hazards Cox regression, there was no significant association between a rehospitalization for\n              <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>\n              and 5\u2010year all\u2010cause mortality (9.6% versus 13.8%; adjusted hazard ratio 0.87, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.60\u20131.16). Patients rehospitalized for unplanned revascularization had a lower 5\u2010year mortality risk (7.0% versus 15.1%; hazard ratio 0.68, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.50\u20130.92) compared with those without such rehospitalizations. Nevertheless, patients with\n              <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>\n              and unplanned revascularization had a substantially greater hazard of subsequent rehospitalizations compared with patients without such events (\n              <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>\n              : hazard ratio 4.36, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              3.48\u20135.47; revascularization: hazard ratio 4.38, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              3.53\u20135.44).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Rehospitalizations for\n              <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>\n              and unplanned revascularization in the year after an acute myocardial infarction are associated with higher risks of subsequent rehospitalizations but not with mortality.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.115.003129","type":"journal-article","created":{"date-parts":[[2016,8,21]],"date-time":"2016-08-21T00:28:18Z","timestamp":1471739298000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Relevance of Rehospitalizations for Unstable Angina and Unplanned Revascularization Following Acute Myocardial Infarction"],"prefix":"10.1161","volume":"5","author":[{"given":"Supriya","family":"Shore","sequence":"first","affiliation":[{"name":"Emory University School of Medicine, Atlanta, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim G.","family":"Smolderen","sequence":"additional","affiliation":[{"name":"Ghent University, Ghent, Belgium"},{"name":"Mid America Heart Institute, Kansas City, MO"},{"name":"University of Missouri Kansas City, Kansas City, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Spertus","sequence":"additional","affiliation":[{"name":"Mid America Heart Institute, Kansas City, MO"},{"name":"University of Missouri Kansas City, Kansas City, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin F.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Mid America Heart Institute, Kansas City, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip G.","family":"Jones","sequence":"additional","affiliation":[{"name":"Mid America Heart Institute, Kansas City, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenxiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Duke University, Durham, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne V.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Mid America Heart Institute, Kansas City, MO"},{"name":"University of Missouri Kansas City, Kansas City, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","unstructured":"Centers for Medicare & Medicaid Services . Readmissions reduction program. Available at: http:\/\/www.Cms.Gov\/medicare\/medicare-fee-for-service-payment\/acuteinpatientpps\/readmissions-reduction-program.Html. Accessed October 9 2013."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa0803563"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39136.682083.AE"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.330.7491.594"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.006588"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.110.960468"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.181940"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00397-9"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199603000-00003"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.22.2727"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3263"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(00)00321-8"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2554"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.111.964585"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/circoutcomes.7.suppl_1.283"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001352"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.2017"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.115.003129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:19:11Z","timestamp":1715595551000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.115.003129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,8]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8,8]]}},"alternative-id":["10.1161\/JAHA.115.003129"],"URL":"https:\/\/doi.org\/10.1161\/jaha.115.003129","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,8]]},"assertion":[{"value":"2015-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e003129"}}