{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:08:17Z","timestamp":1792598897227,"version":"4.5.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,5,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Studies have reported increasing incidence of ischemic stroke in adults younger than 50 to 55 years. Information on temporal trends of other stroke subtypes and transient ischemic attack (\n              <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>\n              ) is sparse. The aim of this study was to investigate temporal trends of the incidence of hospitalizations for\n              <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>\n              and stroke including sex\u2010 and subtype\u2010specific trends in young adults aged 15 to 30\u00a0years.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              From the Danish National Patient Register, we identified all cases of first\u2010ever stroke and\n              <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>\n              (age 15\u201330\u00a0years) in Denmark, who were hospitalized during the study period of 1994 to 2012. Incidence rates and estimated annual percentage changes (\n              <jats:styled-content style=\"fixed-case\">EAPCs<\/jats:styled-content>\n              ) were estimated by using Poisson regression. During the study period, 4156 cases of first\u2010ever hospitalization for stroke\/\n              <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>\n              were identified. The age\u2010standardized incidence rates of hospitalizations for stroke increased significantly (\n              <jats:styled-content style=\"fixed-case\">EAPC<\/jats:styled-content>\n              1.83% [95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.11\u20132.55%]) from 11.97\/100\u00a0000\u00a0person\u2010years (\n              <jats:styled-content style=\"fixed-case\">PY<\/jats:styled-content>\n              ) in 1994 to 16.77\/100\u00a0000\u00a0\n              <jats:styled-content style=\"fixed-case\">PY<\/jats:styled-content>\n              in 2012.\n              <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>\n              hospitalizations increased from 1.93\/100\u00a0000\u00a0\n              <jats:styled-content style=\"fixed-case\">PY<\/jats:styled-content>\n              in 1994 to 5.81\/100\u00a0000\u00a0\n              <jats:styled-content style=\"fixed-case\">PY<\/jats:styled-content>\n              in 2012 and after 2006 more markedly in men than in women (\n              <jats:styled-content style=\"fixed-case\">EAPC<\/jats:styled-content>\n              16.61% [95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              10.45\u201323.12%]). The incidence of hospitalizations for ischemic stroke was markedly lower among men, but increased significantly from 2006 (\n              <jats:styled-content style=\"fixed-case\">EAPC<\/jats:styled-content>\n              14.60% [95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              6.22\u201323.63%]). The incidences of hospitalizations for intracerebral hemorrhage and subarachnoid hemorrhage remained stable during the study period.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The incidence rates of first\u2010time hospitalizations for ischemic stroke and\n              <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>\n              in young Danish adults have increased substantially since the mid 1990s. The increase was particularly prominent in the most recent years.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.115.003158","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T04:43:48Z","timestamp":1463028228000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":131,"title":["Increasing Incidence of Hospitalization for Stroke and Transient Ischemic Attack in Young Adults: A Registry\u2010Based Study"],"prefix":"10.1161","volume":"5","author":[{"given":"Maiken","family":"Tib\u00e6k","sequence":"first","affiliation":[{"name":"Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Dehlendorff","sequence":"additional","affiliation":[{"name":"Statistics, Bioinformatics and Registry, Danish Cancer Society Research Center, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik S.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Research Unit on Brain Injury Rehabilitation Copenhagen (RUBRIC), TBI Unit, Department of Neurorehabilitation, Rigshospitalet, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hysse B.","family":"Forchhammer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren P.","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars P.","family":"Kammersgaard","sequence":"additional","affiliation":[{"name":"Research Unit on Brain Injury Rehabilitation Copenhagen (RUBRIC), TBI Unit, Department of Neurorehabilitation, Rigshospitalet, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.06.025"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.677724"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-13-156"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61953-4"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12469"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304207"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005205"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-306203"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.529883"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001170"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811399958"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000102143"},{"key":"e_1_3_3_16_2","unstructured":"Statistics Denmark . 2016. 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