{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:37:58Z","timestamp":1793738278616,"version":"4.6.1"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,8,8]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Obstructive sleep apnea (\n                      <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>\n                      ) is an important risk factor for the development of cardiovascular diseases including myocardial infarction (\n                      <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                      ). The aim of this study was to investigate the effects of\n                      <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>\n                      on prognosis after\n                      <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                      , and to determine which specific measures of\n                      <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>\n                      severity best predicted outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We performed a prospective study, in which 112 patients without a prior diagnosis of sleep apnea underwent comprehensive polysomnography within a median of 7\u00a0days after\n                      <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                      . Patients were followed up at 6\u2010monthly intervals (\u00b12\u00a0weeks) for a total of 48\u00a0months. Patients classified with central apnea (n=6) or those using continuous positive airway pressure (n=8) after polysomnography were excluded from analyses. The primary end point was major adverse cardiac events, including death from any cause, recurrent\n                      <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                      , unstable angina, heart failure, stroke, and significant arrhythmic events. Forty of 98 patients (41%) had\n                      <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>\n                      (apnea\u2010hypopnea index \u226515\u00a0events\/h).\n                      <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>\n                      patients had higher major adverse cardiac event rates when compared to those without\n                      <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>\n                      (47.5% versus 24.1%; \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      =5.41,\n                      <jats:italic>P<\/jats:italic>\n                      =0.020). In a multivariate model that adjusted for clinically relevant variables including age, left ventricular ejection fraction, diabetes mellitus, oxygen desaturation index, and arousal index, significant hypoxemia, as defined by nocturnal nadir oxygen saturation \u226485%, was an independent risk factor for major adverse cardiac events (hazard ratio=6.05,\n                      <jats:italic>P<\/jats:italic>\n                      =0.004) in follow\u2010up 15\u00a0months after baseline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Nocturnal hypoxemia in\n                      <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>\n                      is an important predictor of poor prognosis for patients after\n                      <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                      . These findings suggest that routine use of low\u2010cost nocturnal oximetry may be an economical and practical approach to stratify risk in post\u2010\n                      <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                      patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.115.003162","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T23:34:33Z","timestamp":1469662473000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":83,"title":["Nocturnal Hypoxemia Due to Obstructive Sleep Apnea Is an\u00a0Independent Predictor of Poor Prognosis After Myocardial Infarction"],"prefix":"10.1161","volume":"5","author":[{"given":"Jiang","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN"},{"name":"Pulmonary Department of Beijing An Zhen Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima H.","family":"Sert Kuniyoshi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naima","family":"Covassin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachi","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apoor S.","family":"Gami","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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