{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:14:53Z","timestamp":1790810093195,"version":"4.1.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,5,6]]},"abstract":"\n Background<\/jats:title>\n \n The significance of hospital readmission after endovascular therapy for critical limb ischemia (\n CLI<\/jats:styled-content>\n ) is not well established. We sought to investigate the incidence, timing, and causes of readmissions after endovascular therapy for\n CLI<\/jats:styled-content>\n and whether readmission is associated with major adverse limb events (\n MALE<\/jats:styled-content>\n ) or mortality.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n This was a retrospective study of 252 patients treated with endovascular therapy for\n CLI<\/jats:styled-content>\n . During median follow\u2010up of 381\u00a0days (interquartile range [\n IQR<\/jats:styled-content>\n ], 115\u2013718), 140 (56%) were readmitted, with median time to readmission of 83\u00a0days (\n IQR,<\/jats:styled-content>\n 33\u2013190). Readmission within 30\u00a0days occurred in 14% of patients (n=35; 25% of readmissions). Most readmissions occurred between 30 and 180\u00a0days (n=67; 48% of readmissions). The most frequent reason for readmission was unhealed wounds (n=63; 45% of readmissions). Independent predictors of readmission by Cox proportional hazards analysis were unhealed wounds, presence of multiple wounds, age \u226570, female sex, hemodialysis, and history of heart failure (\n P<\/jats:italic>\n <0.05 for each). By Kaplan\u2013Meier analysis, readmission was greatest in patients with unhealed wounds, followed by patients who never had a wound, and lowest in patients whose wounds completely healed (\n P<\/jats:italic>\n <0.0001 overall, and\n P<\/jats:italic>\n <0.01 between groups). After multivariable adjustment, readmission remained an independent predictor of composite\n MALE<\/jats:styled-content>\n (major amputation, bypass, or endarterectomy) or mortality (adjusted hazard ratio, 3.1; 95%\n CI<\/jats:styled-content>\n , 1.5\u20136.5;\n P<\/jats:italic>\n =0.002).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Most readmissions occur 30 and 180\u00a0days after endovascular therapy for nonprocedural reasons. Unhealed wounds are an independent risk factor for readmission. Readmission is associated with increased\n MALE<\/jats:styled-content>\n and mortality after endovascular therapy for\n CLI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.003168","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T16:25:46Z","timestamp":1464020746000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Hospital Readmissions Following Endovascular Therapy for Critical Limb Ischemia: Associations With Wound Healing, Major Adverse Limb Events, and Mortality"],"prefix":"10.1161","volume":"5","author":[{"given":"Grant W.","family":"Reed","sequence":"first","affiliation":[{"name":"Heart and Vascular Institute, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pejman","family":"Raeisi\u2010Giglou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Kafa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umair","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Salehi","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi H.","family":"Shishehbor","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.125435"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.72"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.12.055"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1538574415593498"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.09.044"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.12.037"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.174526"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2009.06.020"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2014.02.003"},{"key":"e_1_3_2_11_2","first-page":"361","volume-title":"Vascular Surgery","author":"Taylor L","year":"1998","unstructured":"Taylor L, Porter J. 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