{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:28:35Z","timestamp":1787761715333,"version":"build-2784847793"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,6,13]]},"abstract":"\n Background<\/jats:title>\n \n Preimplantation balloon aortic valvuloplasty (\n BAV<\/jats:styled-content>\n ) is considered a routine procedure during transcatheter aortic valve implantation (\n TAVI<\/jats:styled-content>\n ) to facilitate prosthesis implantation and expansion; however, it has been speculated that fewer embolic events and\/or less hemodynamic instability may occur if\n TAVI<\/jats:styled-content>\n is performed without preimplantation\n BAV<\/jats:styled-content>\n . The aim of this study was to systematically review the clinical outcomes associated with\n TAVI<\/jats:styled-content>\n undertaken without preimplantation\n BAV<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We conducted a search of Medline and Embase to identify studies that evaluated patients who underwent\n TAVI<\/jats:styled-content>\n with or without preimplantation\n BAV<\/jats:styled-content>\n for predilation. Pooled analysis and random\u2010effects meta\u2010analyses were used to estimate the rate and risk of adverse outcomes. Sixteen studies involving 1395 patients (674 with and 721 without preimplantation\n BAV<\/jats:styled-content>\n ) fulfilled the inclusion criteria. Crude device success was achieved in 94% (1311 of 1395), and 30\u2010day all\u2010cause mortality occurred in 6% (72 of 1282) of patients. Meta\u2010analyses evaluating outcomes of strategies with and without preimplantation\n BAV<\/jats:styled-content>\n showed no statistically significant differences in terms of mortality (relative risk [\n RR<\/jats:styled-content>\n ] 0.61, 95%\n CI<\/jats:styled-content>\n 0.32\u20131.14,\n P<\/jats:italic>\n =0.12), safety composite end point (\n RR<\/jats:styled-content>\n 0.85, 95%\n CI<\/jats:styled-content>\n 0.62\u20131.18,\n P<\/jats:italic>\n =0.34), moderate to severe paravalvular leaks (\n RR<\/jats:styled-content>\n 0.68, 95%\n CI<\/jats:styled-content>\n 0.23\u20131.99,\n P<\/jats:italic>\n =0.48), need for postdilation (\n RR<\/jats:styled-content>\n 0.86, 95%\n CI<\/jats:styled-content>\n 0.66\u20131.13,\n P<\/jats:italic>\n =0.58), stroke and\/or transient ischemic attack (\n RR<\/jats:styled-content>\n 0.72, 95%\n CI<\/jats:styled-content>\n 0.30\u20131.71,\n P<\/jats:italic>\n =0.45), and permanent pacemaker implantation (\n RR<\/jats:styled-content>\n 0.80, 95%\n CI<\/jats:styled-content>\n 0.49\u20131.30,\n P<\/jats:italic>\n =0.37).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Our analysis suggests that\n TAVI<\/jats:styled-content>\n procedures with or without preimplantation\n BAV<\/jats:styled-content>\n were associated with similar outcomes for a number of clinically relevant end points. Further studies including a large number of patients are needed to ascertain the impact of\n TAVI<\/jats:styled-content>\n without preimplantation\n BAV<\/jats:styled-content>\n as a standard practice.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.115.003191","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T03:00:59Z","timestamp":1465873259000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["Transcatheter Aortic Valve Implantation With or Without Preimplantation Balloon Aortic Valvuloplasty: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1161","volume":"5","author":[{"given":"Rodrigo","family":"Bagur","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, London Health Sciences Centre, Western University, London, Ontario, Canada"},{"name":"Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Shing","family":"Kwok","sequence":"additional","affiliation":[{"name":"Royal Stoke University Hospital, Stoke\u2010on\u2010Trent, Staffordshire, United Kingdom"},{"name":"Keele Cardiovascular Research Group, Institute of Science and Technology in Medicine and Primary Care, Keele University, Stoke\u2010on\u2010Trent, Staffordshire, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Nombela\u2010Franco","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter F.","family":"Ludman","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"de Belder","sequence":"additional","affiliation":[{"name":"James Cook University Hospital, Middlesbrough, North Yorkshire, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Sponga","sequence":"additional","affiliation":[{"name":"Cardiothoracic Department, University Hospital of Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Gunning","sequence":"additional","affiliation":[{"name":"Royal Stoke University Hospital, Stoke\u2010on\u2010Trent, Staffordshire, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Nolan","sequence":"additional","affiliation":[{"name":"Royal Stoke University Hospital, Stoke\u2010on\u2010Trent, Staffordshire, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pantelis","family":"Diamantouros","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, London Health Sciences Centre, Western University, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Teefy","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, London Health Sciences Centre, Western University, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob","family":"Kiaii","sequence":"additional","affiliation":[{"name":"Department of Surgery, Western University, London, Ontario, Canada"},{"name":"Division of Cardiac Surgery, London Health Sciences Centre, University Hospital, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W. 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