{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T16:42:55Z","timestamp":1776962575029,"version":"3.51.4"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,7,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Coronary artery spasm (\n              <jats:styled-content style=\"fixed-case\">CAS<\/jats:styled-content>\n              ) is a well\u2010known endothelial dysfunction, and a major cause of vasospastic angina (\n              <jats:styled-content style=\"fixed-case\">VSA<\/jats:styled-content>\n              ). The renin\u2013angiotensin system (\n              <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>\n              ) is known to be closely associated with endothelial function. However, there are only a few studies that investigated the impact of\n              <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>\n              inhibitor on long\u2010term clinical outcomes in\n              <jats:styled-content style=\"fixed-case\">VSA<\/jats:styled-content>\n              patients.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 3349 patients with no significant coronary artery disease, diagnosed with\n              <jats:styled-content style=\"fixed-case\">CAS<\/jats:styled-content>\n              by acetylcholine provocation test were enrolled for this study. Significant\n              <jats:styled-content style=\"fixed-case\">CAS<\/jats:styled-content>\n              was defined as having \u226570% narrowing of the artery after incremental injections of 20, 50, and 100\u00a0\u03bcg of acetylcholine into the left coronary artery. Patients were divided into 2 groups according to whether the prescription included\n              <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>\n              inhibitor or not (\n              <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>\n              inhibitor group: n=666, non\u2010\n              <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>\n              inhibitor group; n=2683). To adjust for any potential confounders that could cause bias, propensity score matching (\n              <jats:styled-content style=\"fixed-case\">PSM<\/jats:styled-content>\n              ) analysis was performed using a logistic regression model. After\n              <jats:styled-content style=\"fixed-case\">PSM<\/jats:styled-content>\n              analysis, 2 matched groups (524 pairs, n=1048 patients, C\u2010statistic=0.845) were generated and their baseline characteristics were balanced. During the 5\u2010year clinical follow\u2010up, the\n              <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>\n              inhibitor group showed a lower incidence of recurrent angina (8.7% versus 14.1%,\n              <jats:italic>P<\/jats:italic>\n              =0.027), total death (0.0% versus 1.3%,\n              <jats:italic>P<\/jats:italic>\n              =0.045), and total major adverse cardiovascular events (1.0% versus 4.1%,\n              <jats:italic>P<\/jats:italic>\n              =0.026) than the non\u2010\n              <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>\n              inhibitor group.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Chronic\n              <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>\n              inhibitor therapy was associated with lower incidence of cardiovascular events in\n              <jats:styled-content style=\"fixed-case\">VSA<\/jats:styled-content>\n              patients in the 5\u2010year clinical follow\u2010up.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.003217","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T01:34:18Z","timestamp":1469151258000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Impact of Renin\u2010Angiotensin System Inhibitors on Long\u2010Term Clinical Outcomes of Patients With Coronary Artery Spasm"],"prefix":"10.1161","volume":"5","author":[{"given":"Byoung Geol","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Medicine, Korea University Graduate School, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Yeon","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Medicine, Korea University Graduate School, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Woon","family":"Rha","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang\u2010Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiology Department, Soonchunhyang University Cheonan Hospital, Cheonan, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Suk","family":"Shim","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se Yeon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Korea University Graduate School, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Kyeong","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Medicine, Korea University Graduate School, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine, Korea University Graduate School, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jah Yeon","family":"Choi","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Hun","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Joong","family":"Lee","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunki","family":"Lee","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Oh","family":"Na","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol Ung","family":"Choi","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Euy","family":"Lim","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eung Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Gyu","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Seog","family":"Seo","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Joo","family":"Oh","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.037283"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2011.01.012"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.04.050"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(00)00469-1"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.02.021"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.004096"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2008.01.001"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.843474"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.08.626"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-11-0056"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu313"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.4.575"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.84.suppl_1.i20"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.12.106"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2009.40"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2009.05273.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2012.02.007"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu427"},{"key":"e_1_3_3_20_2","first-page":"1","article-title":"Renin\u2010angiotensin system inhibitor and statins combination therapeutics\u2014what have we learnt?","author":"Koh KK","year":"2015","unstructured":"Koh KK, Sakuma I, Hayashi T, Kim SH, Chung WJ. Renin\u2010angiotensin system inhibitor and statins combination therapeutics\u2014what have we learnt? Expert Opin Pharmacother. 2015:1\u20135.","journal-title":"Expert Opin Pharmacother"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-012-0249-2"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.051"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0773"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.2.473"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-12-1486"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.116.003217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:12:41Z","timestamp":1715595161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.116.003217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,6]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7,6]]}},"alternative-id":["10.1161\/JAHA.116.003217"],"URL":"https:\/\/doi.org\/10.1161\/jaha.116.003217","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,6]]},"assertion":[{"value":"2016-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e003217"}}