{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:26:09Z","timestamp":1767651969740,"version":"3.41.2"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,7,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">End\u2010stage renal disease is accompanied by functional and structural vascular abnormalities. The objective of this study was to characterize vascular function in a large cohort of patients with end\u2010stage renal disease, using noninvasive physiological measurements, and to correlate function with demographic and clinical factors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We analyzed cross\u2010sectional baseline data from the Hemodialysis Fistula Maturation Study, a multicenter prospective observational cohort study of 602 patients with end\u2010stage renal disease from 7 centers. Brachial artery flow\u2010 and nitroglycerin\u2010mediated dilation, carotid\u2010femoral and \u2010radial pulse wave velocity, and venous occlusion plethysmography were performed prior to arteriovenous fistula creation. Relationships of these vascular function measures with demographic, clinical, and laboratory factors were evaluated using linear mixed\u2010effects models. Arterial function, as assessed by flow\u2010 and nitroglycerin\u2010mediated dilation and carotid\u2010femoral pulse wave velocity, worsened with increasing age and diabetes mellitus. Venous capacitance decreased with diabetes mellitus but not with age. Flow\u2010mediated dilation was higher among patients undergoing maintenance dialysis than for those at predialysis, and a U\u2010shaped relationship between serum phosphorus concentration and flow\u2010mediated dilation was evident. Partial correlations among different measures of vascular function, adjusting for demographic factors, diabetes mellitus, and clinical center, were modest or essentially nonexistent.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Multiple demographic and clinical factors were associated with the functions of vessels of different sizes and types in this large cohort of patients with end\u2010stage renal disease. Low correlations between the different measures, controlling for demographic factors, diabetes mellitus, and center, indicated that these different types of vascular function otherwise vary heterogeneously across patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.003227","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T10:10:42Z","timestamp":1505729442000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Vascular Function at Baseline in the Hemodialysis Fistula Maturation Study"],"prefix":"10.1161","volume":"5","author":[{"given":"Laura M.","family":"Dember","sequence":"first","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter B.","family":"Imrey","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, 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