{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:39:00Z","timestamp":1790444340431,"version":"4.1.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,5,6]]},"abstract":"\n Background<\/jats:title>\n \n Mitochondrial aldehyde dehydrogenase 2 (\n ALDH<\/jats:styled-content>\n 2) plays a key role in removing toxic aldehydes. Deficient variant\n \n ALDH<\/jats:styled-content>\n 2*2\n <\/jats:italic>\n genotype is prevalent in up to 40% of the East Asians and reported to be associated with acute myocardial infarction (\n AMI<\/jats:styled-content>\n ). To elucidate the mechanisms underlying the association of\n \n ALDH<\/jats:styled-content>\n 2*2\n <\/jats:italic>\n with\n AMI<\/jats:styled-content>\n , we compared the clinical features of\n AMI<\/jats:styled-content>\n patients with\n \n ALDH<\/jats:styled-content>\n 2*2\n <\/jats:italic>\n to those with wild\u2010type\n \n ALDH<\/jats:styled-content>\n 2*1\/*1\n <\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n The study subjects consisted of 202 Japanese patients with acute\n ST\u2010<\/jats:styled-content>\n segment elevation myocardial infarction (\n STEMI<\/jats:styled-content>\n ) (156 men and 46 women; mean age, 67.3\u00b112.0) who underwent primary percutaneous coronary intervention (\n PCI<\/jats:styled-content>\n ). In 85 patients, provocation test for coronary spasm was also done 6\u00a0month post\u2010\n PCI<\/jats:styled-content>\n .\n \n ALDH<\/jats:styled-content>\n 2\n <\/jats:italic>\n genotyping was performed by direct application of the TaqMan polymerase chain system. Of the 202 patients, 103 (51.0%) were carriers of\n \n ALDH<\/jats:styled-content>\n 2*2\n <\/jats:italic>\n and 99 (49.0%) those of\n \n ALDH<\/jats:styled-content>\n 2*1\/*1\n <\/jats:italic>\n . There were no differences in clinical features between\n \n ALDH<\/jats:styled-content>\n 2*2\n <\/jats:italic>\n and\n \n ALDH<\/jats:styled-content>\n 2*1\/*1\n <\/jats:italic>\n carrier groups except higher frequencies of coronary spasm and alcohol flush syndrome (\n AFS<\/jats:styled-content>\n ) (88.6% vs 56.1%;\n P<\/jats:italic>\n =0.001 and 94.3% vs 17.6%;\n P<\/jats:italic>\n <0.001), less\u2010frequent alcohol habit (14.6% vs 51.5%;\n P<\/jats:italic>\n <0.001), and higher peak plasma creatine phophokinase levels (2224\u00a0vs 1617\u00a0mg\/\n dL<\/jats:styled-content>\n ;\n P<\/jats:italic>\n =0.002) in the\n \n ALDH<\/jats:styled-content>\n 2*2\n <\/jats:italic>\n than the\n \n ALDH<\/jats:styled-content>\n 2*1\/*1\n <\/jats:italic>\n carrier group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n ALDH<\/jats:styled-content>\n 2*2\n <\/jats:italic>\n is prevalent (51.0%) among Japanese\n STEMI<\/jats:styled-content>\n patients, and those with\n \n ALDH<\/jats:styled-content>\n 2*2\n <\/jats:italic>\n had higher frequencies of coronary spasm and\n AFS<\/jats:styled-content>\n and more\u2010severe myocardial injury compared to those with\n \n ALDH<\/jats:styled-content>\n 2*1\/*1\n <\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.003247","type":"journal-article","created":{"date-parts":[[2016,5,7]],"date-time":"2016-05-07T08:23:00Z","timestamp":1462609380000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":50,"title":["Variant Aldehyde Dehydrogenase 2 (\n ALDH2*2<\/i>\n ) Is a Risk Factor for Coronary Spasm and ST\u2010Segment Elevation Myocardial Infarction"],"prefix":"10.1161","volume":"5","author":[{"given":"Yuji","family":"Mizuno","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto, 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