{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:28:57Z","timestamp":1789950537202,"version":"4.0.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,3,9]]},"abstract":"\n Background<\/jats:title>\n \n No data are available on the long\u2010term performance of ultrathin strut biodegradable polymer sirolimus\u2010eluting stents (\n BP<\/jats:styled-content>\n \u2010\n SES<\/jats:styled-content>\n ). We reported 2\u2010year clinical outcomes of the\n BIOSCIENCE<\/jats:styled-content>\n (Ultrathin Strut Biodegradable Polymer Sirolimus\u2010Eluting Stent Versus Durable Polymer Everolimus\u2010Eluting Stent for Percutaneous Coronary Revascularisation) trial, which compared\n BP<\/jats:styled-content>\n \u2010\n SES<\/jats:styled-content>\n with durable\u2010polymer everolimus\u2010eluting stents (\n DP<\/jats:styled-content>\n \u2010\n EES<\/jats:styled-content>\n ) in patients undergoing percutaneous coronary intervention.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n A total of 2119 patients with minimal exclusion criteria were assigned to treatment with\n BP<\/jats:styled-content>\n \u2010\n SES<\/jats:styled-content>\n (n=1063) or\n DP<\/jats:styled-content>\n \u2010\n EES<\/jats:styled-content>\n (n=1056). Follow\u2010up at 2\u00a0years was available for 2048 patients (97%). The primary end point was target\u2010lesion failure, a composite of cardiac death, target\u2010vessel myocardial infarction, or clinically indicated target\u2010lesion revascularization. At 2\u00a0years,\n target\u2010lesion failure<\/jats:styled-content>\n occurred in 107 patients (10.5%) in the\n BP<\/jats:styled-content>\n \u2010\n SES<\/jats:styled-content>\n arm and 107 patients (10.4%) in the\n DP<\/jats:styled-content>\n \u2010\n EES<\/jats:styled-content>\n arm (risk ratio [\n RR<\/jats:styled-content>\n ] 1.00, 95%\n CI<\/jats:styled-content>\n 0.77\u20131.31,\n P<\/jats:italic>\n =0.979). There were no significant differences between\n BP<\/jats:styled-content>\n \u2010\n SES<\/jats:styled-content>\n and\n DP<\/jats:styled-content>\n \u2010\n EES<\/jats:styled-content>\n with respect to cardiac death (\n RR<\/jats:styled-content>\n 1.01, 95%\n CI<\/jats:styled-content>\n 0.62\u20131.63,\n P<\/jats:italic>\n =0.984), target\u2010vessel myocardial infarction (\n RR<\/jats:styled-content>\n 0.91, 95%\n CI<\/jats:styled-content>\n 0.60\u20131.39,\n P<\/jats:italic>\n =0.669),\n target\u2010lesion revascularization<\/jats:styled-content>\n (\n RR<\/jats:styled-content>\n 1.17, 95%\n CI<\/jats:styled-content>\n 0.81\u20131.71,\n P<\/jats:italic>\n =0.403), and definite stent thrombosis (\n RR<\/jats:styled-content>\n 1.38, 95%\n CI<\/jats:styled-content>\n 0.56\u20133.44,\n P<\/jats:italic>\n =0.485). There were 2 cases (0.2%) of definite very late stent thrombosis in the\n BP<\/jats:styled-content>\n \u2010\n SES<\/jats:styled-content>\n arm and 4 cases (0.4%) in the\n DP<\/jats:styled-content>\n \u2010\n EES<\/jats:styled-content>\n arm (\n P<\/jats:italic>\n =0.423). In the prespecified subgroup of patients with\n ST<\/jats:styled-content>\n \u2010segment elevation myocardial infarction,\n BP<\/jats:styled-content>\n \u2010\n SES<\/jats:styled-content>\n was associated with a lower risk of\n target\u2010lesion failure<\/jats:styled-content>\n compared with\n DP<\/jats:styled-content>\n \u2010\n EES<\/jats:styled-content>\n (\n RR<\/jats:styled-content>\n 0.48, 95%\n CI<\/jats:styled-content>\n 0.23\u20130.99,\n P<\/jats:italic>\n =0.043,\n P<\/jats:italic>\n interaction<\/jats:sub>\n =0.026).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Comparable safety and efficacy profiles of\n BP<\/jats:styled-content>\n \u2010\n SES<\/jats:styled-content>\n and\n DP<\/jats:styled-content>\n \u2010\n EES<\/jats:styled-content>\n were maintained throughout 2\u00a0years of follow\u2010up.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n . Unique identifier:\n NCT<\/jats:styled-content>\n 01443104.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.003255","type":"journal-article","created":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T02:53:41Z","timestamp":1458096821000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Ultrathin Strut Biodegradable Polymer Sirolimus\u2010Eluting Stent Versus Durable\u2010Polymer Everolimus\u2010Eluting Stent for Percutaneous Coronary Revascularization: 2\u2010Year Results of the BIOSCIENCE Trial"],"prefix":"10.1161","volume":"5","author":[{"given":"Rainer","family":"Zbinden","sequence":"first","affiliation":[{"name":"Department of Cardiology, Triemlispital, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Piccolo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Swiss Cardiovascular Center, University Hospital, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dik","family":"Heg","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine and Clinical Trials Unit, Bern University Hospital, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Roffi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Kurz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Triemlispital, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Muller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Vuilliomenet","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kantonsspital, Aarau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, Fribourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Weilenmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kantonsspital, St. Gallen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiman","family":"Jamshidi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kantonsspital, Luzern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Franzone","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Swiss Cardiovascular Center, University Hospital, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Eberli","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Triemlispital, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"J\u00fcni","sequence":"additional","affiliation":[{"name":"Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Swiss Cardiovascular Center, University Hospital, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pilgrim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Swiss Cardiovascular Center, University Hospital, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu278"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)61220-X"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.683995"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1210816"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.002223"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g3859"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61038-2"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.06.004"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.04.011"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.045"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-1558"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV11I3A53"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.002817"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6530"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht570"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1586\/17434440.2014.894458"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.003210"},{"key":"e_1_3_4_20_2","unstructured":"Jensen 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Randomised comparison of a sirolimus\u2010eluting stent with a biolimus\u2010eluting stent in patients treated with PCI: the SORT OUT VII trial. Presented at EuroPCR 2015 Paris. 2015. Available at: http:\/\/www.pcronline.com\/Lectures\/2015\/Randomised-comparison-of-a-sirolimus-eluting-stent-with-a-biolimus-eluting-stent-in-patients-treated-with-PCI-the-SORT-OUT-VII-trial. 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