{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:15:38Z","timestamp":1790072138768,"version":"4.0.1"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,6,13]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Sleep\u2010disordered breathing (\n              <jats:styled-content style=\"fixed-case\">SDB<\/jats:styled-content>\n              ) has been recognized as an important risk factor for cardiovascular diseases; however, the impact of\n              <jats:styled-content style=\"fixed-case\">SDB<\/jats:styled-content>\n              on long\u2010term outcomes in patients with acute coronary syndrome has not been fully evaluated.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We performed overnight cardiorespiratory monitoring of 241 patients with acute coronary syndrome who were successfully treated with primary percutaneous coronary intervention between January 2005 and December 2008. The presence of\n              <jats:styled-content style=\"fixed-case\">SDB<\/jats:styled-content>\n              was defined as apnea\u2013hypopnea index \u22655\u00a0events per hour. The end point was incidence of major adverse cardiocerebrovascular events, defined as a composite of all\u2010cause death, recurrence of acute coronary syndrome, nonfatal stroke, and hospital admission for congestive heart failure. Patients were followed for a median period of 5.6\u00a0years. Among the 241 patients who were finally enrolled, comorbidity of\n              <jats:styled-content style=\"fixed-case\">SDB<\/jats:styled-content>\n              with acute coronary syndrome was found in 126 patients (52.3%). The cumulative incidence of major adverse cardiocerebrovascular events was significantly higher in patients with\n              <jats:styled-content style=\"fixed-case\">SDB<\/jats:styled-content>\n              than in those without\n              <jats:styled-content style=\"fixed-case\">SDB<\/jats:styled-content>\n              (21.4% versus 7.8%,\n              <jats:italic>P<\/jats:italic>\n              =0.006). Multivariable analysis revealed that the presence of\n              <jats:styled-content style=\"fixed-case\">SDB<\/jats:styled-content>\n              was a significant predictor of major adverse cardiocerebrovascular events (hazard ratio 2.28, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.06\u20134.92;\n              <jats:italic>P<\/jats:italic>\n              =0.035).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The study's results showed that the presence of\n              <jats:styled-content style=\"fixed-case\">SDB<\/jats:styled-content>\n              among patients with acute coronary syndrome following primary percutaneous coronary intervention is associated with a higher incidence of major adverse cardiocerebrovascular events during long\u2010term follow\u2010up.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.003270","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T06:02:46Z","timestamp":1466056966000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Impact of Sleep\u2010Disordered Breathing on Long\u2010Term Outcomes in Patients With Acute Coronary Syndrome Who Have Undergone Primary Percutaneous Coronary Intervention"],"prefix":"10.1161","volume":"5","author":[{"given":"Toru","family":"Mazaki","sequence":"first","affiliation":[{"name":"Department of Cardiology, Kobe Central Hospital, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takatoshi","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo, Japan"},{"name":"Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyoshi","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukuoka Sanno Hospital, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichi","family":"Kuramitsu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyohei","family":"Yamaji","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Morinaga","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisaki","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.070813"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.901801"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.1.9905035"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.10.2101072"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.07.055"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.783290"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.1464"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.04.011"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.06.010"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192663"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0b013e318212bb8b"},{"key":"e_1_3_3_13_2","first-page":"119","article-title":"Comparison of tongue volume\/oral cavity volume ratio between obstructive sleep apnea syndrome patients and normal adults using magnetic resonance imaging","volume":"53","author":"Iida\u2010Kondo C","year":"2006","unstructured":"Iida\u2010Kondo C, Yoshino N, Kurabayashi T, Mataki S, Hasegawa M, Kurosaki N. 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