{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:31:52Z","timestamp":1787920312437,"version":"build-2784847793"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,10,26]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We aim to determine the prevalence of anemia in acute coronary syndrome (\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              ) patients and compare their clinical characteristics, management, and clinical outcomes to those without anemia in an unselected national\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              cohort.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The Myocardial Ischemia National Audit Project (\n              <jats:styled-content style=\"fixed-case\">MINAP<\/jats:styled-content>\n              ) registry collects data on all adults admitted to hospital trusts in England and Wales with diagnosis of an\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              . We conducted a retrospective cohort study by analyzing patients in this registry between January 2006 and December 2010 and followed them up until August 2011. Multiple logistic regressions were used to determine factors associated with anemia and the adjusted odds of 30\u2010day mortality with 1\u00a0g\/dL incremental hemoglobin increase and the 30\u2010day and 1\u2010year mortality for anemic compared to nonanemic groups. Analyses were adjusted for covariates. Our analysis of 422\u00a0855 patients with\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              showed that 27.7% of patients presenting with\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              are anemic and that these patients are older, have a greater prevalence of renal disease, peripheral vascular disease, diabetes mellitus, and previous acute myocardial infarction, and are less likely to receive evidence\u2010based therapies shown to improve clinical outcomes. Finally, our analysis suggests that anemia is independently associated with 30\u2010day (\n              <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n              1.28, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.22\u20101.35) and 1\u2010year mortality (\n              <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n              1.31, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.27\u20101.35), and we observed a reverse J\u2010shaped relationship between hemoglobin levels and mortality outcomes.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The prevalence of anemia in a contemporary national\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              cohort is clinically significant. Patients with anemia are older and multimorbid and less likely to receive evidence\u2010based therapies shown to improve clinical outcomes, with the presence of anemia independently associated with mortality outcomes.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.003348","type":"journal-article","created":{"date-parts":[[2016,11,20]],"date-time":"2016-11-20T01:20:15Z","timestamp":1479604815000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":84,"title":["Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights From the UK Myocardial Ischemia National Audit Project Registry"],"prefix":"10.1161","volume":"5","author":[{"given":"Mamas A.","family":"Mamas","sequence":"first","affiliation":[{"name":"Keele Cardiovascular Research Group, Institutes of Science and Technology in Medicine and Primary Care and Health Sciences, Keele University, Stoke\u2010on\u2010Trent, United Kingdom"},{"name":"Royal Stoke Hospital, University Hospital North Midlands, Stoke\u2010on\u2010Trent, United Kingdom"},{"name":"Farr Institute, University of Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Shing","family":"Kwok","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, Institutes of Science and Technology in Medicine and Primary Care and Health Sciences, Keele University, Stoke\u2010on\u2010Trent, United Kingdom"},{"name":"Royal Stoke Hospital, University Hospital North Midlands, Stoke\u2010on\u2010Trent, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Kontopantelis","sequence":"additional","affiliation":[{"name":"Farr Institute, University of Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony A.","family":"Fryer","sequence":"additional","affiliation":[{"name":"Institute of Science and Technology in Medicine, Keele University, Stoke\u2010on\u2010Trent, United Kingdom"},{"name":"Royal Stoke Hospital, University Hospital North Midlands, Stoke\u2010on\u2010Trent, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Buchan","sequence":"additional","affiliation":[{"name":"Farr Institute, University of Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max O.","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia, Norwich, United Kingdom"},{"name":"Norwich Research Park Cardiovascular Research Group, Norwich, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Justin","family":"Zaman","sequence":"additional","affiliation":[{"name":"Norwich Research Park Cardiovascular Research Group, Norwich, United Kingdom"},{"name":"Department of Medicine, James Paget University Hospital, Gorleston, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyo K.","family":"Myint","sequence":"additional","affiliation":[{"name":"Norwich Research Park Cardiovascular Research Group, Norwich, United Kingdom"},{"name":"Epidemiology Group, Institute of Applied Health Sciences, University of Aberdeen, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm013"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.10.021"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(02)00134-5"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.01.009"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp116"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.09.023"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.01.001"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.10.024"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr236"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000133"},{"key":"e_1_3_6_12_2","first-page":"945","article-title":"Influence of hemoglobin level on in\u2010hospital prognosis in patients with acute coronary syndrome","volume":"61","author":"Gonzalez\u2010Ferrer JJ","year":"2008","unstructured":"Gonzalez\u2010Ferrer JJ, Garcia\u2010Rubira JC, Balcones DV, Gil IN, Barrio RC, Fuentes\u2010Ferrer M, Fernandez\u2010Ortiz A, Macaya C. 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