{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:55:20Z","timestamp":1775080520623,"version":"3.50.1"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,7,6]]},"abstract":"\n Background<\/jats:title>\n \n The risk of stroke imposed by atrial fibrillation (\n AF<\/jats:styled-content>\n ) is significantly greater in women than men; however, the mechanism remains elusive. We hypothesized that left atrial (\n LA<\/jats:styled-content>\n ) remodeling and poor contractile function of\n LA<\/jats:styled-content>\n appendage (\n LAA<\/jats:styled-content>\n ) would be more predominant in women than men among\n AF<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n A total of 579\n AF<\/jats:styled-content>\n patients (216 women vs age\u2010,\n AF<\/jats:styled-content>\n type\u2013, and incidences of heart failure, hypertension, diabetes mellitus, stroke or transient ischemic attack, and vascular disease\u2013matched 363 men, 61.3\u00b110.2\u00a0years old, 70.1% paroxysmal\n AF<\/jats:styled-content>\n ) who underwent\n AF<\/jats:styled-content>\n catheter ablation were included. Sex differences in\n LA<\/jats:styled-content>\n volume index (\n LAVI<\/jats:styled-content>\n ) and\n LAA<\/jats:styled-content>\n emptying flow velocity (\n FV<\/jats:styled-content>\n ) were analyzed in risk factor 0, 1, and \u22652 groups, according to their\n CHA<\/jats:styled-content>\n 2<\/jats:sub>\n DS<\/jats:styled-content>\n 2<\/jats:sub>\n \u2010\n VAS<\/jats:styled-content>\n c scores beyond sex category.\n LAA<\/jats:styled-content>\n \u2010\n FV<\/jats:styled-content>\n was more significantly reduced in women with risk factor \u22652 than in men of the same risk group (\n P<\/jats:italic>\n =0.022). Women showed greater\n LAVI<\/jats:styled-content>\n than their male counterparts in the risk factor \u22652 group (\n P<\/jats:italic>\n <0.001). The majority of female patients with a history of stroke had a large\n LAVI<\/jats:styled-content>\n and low\n LAA<\/jats:styled-content>\n \u2010\n FV<\/jats:styled-content>\n (\n P<\/jats:italic>\n <0.001); however, no such distribution was observed in men (\n P<\/jats:italic>\n =0.596).\n LA<\/jats:styled-content>\n volume index (odds ratio [\n OR<\/jats:styled-content>\n ], 1.038; 95%\n CI<\/jats:styled-content>\n , 1.003\u20131.075,\n P<\/jats:italic>\n =0.035) or\n LAA<\/jats:styled-content>\n \u2010\n FV<\/jats:styled-content>\n (\n OR<\/jats:styled-content>\n , 0.976; 95%\n CI<\/jats:styled-content>\n , 0.952\u20130.999;\n P<\/jats:italic>\n =0.047) was significantly associated with a history of stroke in women.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n More\u2010extensive\n LA<\/jats:styled-content>\n remodeling and deterioration in\n LAA<\/jats:styled-content>\n function were noted in women than in men with high calculated risk of stroke in\n AF<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.003361","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T07:13:00Z","timestamp":1468307580000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Advanced Left Atrial Remodeling and Appendage Contractile Dysfunction in Women Than in Men Among the Patients With Atrial Fibrillation: Potential Mechanism for Stroke"],"prefix":"10.1161","volume":"5","author":[{"given":"Hee Tae","family":"Yu","sequence":"first","affiliation":[{"name":"Yonsei University Health System, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihei Sara","family":"Lee","sequence":"additional","affiliation":[{"name":"Yonsei University Health System, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae\u2010Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Yonsei University Health System, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Sun","family":"Uhm","sequence":"additional","affiliation":[{"name":"Yonsei University Health System, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyoung","family":"Joung","sequence":"additional","affiliation":[{"name":"Yonsei University Health System, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geu\u2010Ru","family":"Hong","sequence":"additional","affiliation":[{"name":"Yonsei University Health System, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon\u2010Hyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Yonsei University Health System, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi Young","family":"Shim","sequence":"additional","affiliation":[{"name":"Yonsei University Health System, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Nam","family":"Pak","sequence":"additional","affiliation":[{"name":"Yonsei University Health System, Seoul, 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