{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:44:58Z","timestamp":1784641498013,"version":"3.55.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,6,13]]},"abstract":"\n Background<\/jats:title>\n \n We evaluated lipoprotein\u2010associated phospholipase A\n 2<\/jats:sub>\n (Lp\u2010\n PLA<\/jats:styled-content>\n 2<\/jats:sub>\n ) activity in patients with stable coronary heart disease before and during treatment with darapladib, a selective Lp\u2010\n PLA<\/jats:styled-content>\n 2<\/jats:sub>\n inhibitor, in relation to outcomes and the effects of darapladib in the\n STABILITY<\/jats:styled-content>\n trial.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Plasma Lp\u2010\n PLA<\/jats:styled-content>\n 2<\/jats:sub>\n activity was determined at baseline (n=14\u00a0500); at 1\u00a0month (n=13\u00a0709); serially (n=100) at 3, 6, and 18\u00a0months; and at the end of treatment. Adjusted Cox regression models evaluated associations between Lp\u2010\n PLA<\/jats:styled-content>\n 2<\/jats:sub>\n activity levels and outcomes. At baseline, the median Lp\u2010\n PLA<\/jats:styled-content>\n 2<\/jats:sub>\n level was 172.4 \u03bcmol\/min per liter (interquartile range 143.1\u2013204.2 \u03bcmol\/min per liter). Comparing the highest and lowest Lp\u2010\n PLA<\/jats:styled-content>\n 2<\/jats:sub>\n quartile groups, the hazard ratios were 1.50 (95% CI 1.23\u20131.82) for the primary composite end point (cardiovascular death, myocardial infarction, or stroke), 1.95 (95% CI 1.29\u20132.93) for hospitalization for heart failure, 1.42 (1.07\u20131.89) for cardiovascular death, and 1.37 (1.03\u20131.81) for myocardial infarction after adjustment for baseline characteristics, standard laboratory variables, and other prognostic biomarkers. Treatment with darapladib led to a \u224865% persistent reduction in median Lp\u2010\n PLA<\/jats:styled-content>\n 2<\/jats:sub>\n activity. There were no associations between on\u2010treatment Lp\u2010\n PLA<\/jats:styled-content>\n 2<\/jats:sub>\n activity or changes of Lp\u2010\n PLA<\/jats:styled-content>\n 2<\/jats:sub>\n activity and outcomes, and there were no significant interactions between baseline and on\u2010treatment Lp\u2010\n PLA<\/jats:styled-content>\n 2<\/jats:sub>\n activity or changes in Lp\u2010\n PLA<\/jats:styled-content>\n 2<\/jats:sub>\n activity levels and the effects of darapladib on outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Although high Lp\u2010\n PLA<\/jats:styled-content>\n 2<\/jats:sub>\n activity was associated with increased risk of cardiovascular events, pharmacological lowering of Lp\u2010\n PLA<\/jats:styled-content>\n 2<\/jats:sub>\n activity by \u224865% did not significantly reduce cardiovascular events in patients with stable coronary heart disease, regardless of the baseline level or the magnitude of change of Lp\u2010\n PLA<\/jats:styled-content>\n 2<\/jats:sub>\n activity.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n . Unique identifier:\n NCT<\/jats:styled-content>\n 00799903.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.003407","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T04:09:22Z","timestamp":1466654962000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["Lipoprotein\u2010Associated Phospholipase A\n 2<\/sub>\n Activity Is a Marker of Risk But Not a Useful Target for Treatment in Patients With Stable Coronary Heart Disease"],"prefix":"10.1161","volume":"5","author":[{"given":"Lars","family":"Wallentin","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden"},{"name":"Uppsala Clinical Research Center (UCR), Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes","family":"Held","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden"},{"name":"Uppsala Clinical Research Center (UCR), Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Canadian VIGOUR Centre, University of Alberta, Edmonton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women's Hospital, Boston, MA"},{"name":"Harvard Clinical Research Institute, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Y.","family":"Davies","sequence":"additional","affiliation":[{"name":"Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B.","family":"Granger","sequence":"additional","affiliation":[{"name":"Medical Center, Duke University, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"Hagstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden"},{"name":"Uppsala Clinical Research Center (UCR), Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Harrington","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stanford University, Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith S.","family":"Hochman","sequence":"additional","affiliation":[{"name":"Department of Medicine, NYU Langone Medical Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Koenig","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II\u2010Cardiology, University of Ulm Medical Center, Ulm, Germany"},{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Krug\u2010Gourley","sequence":"additional","affiliation":[{"name":"Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Emile R.","family":"Mohler","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agneta","family":"Siegbahn","sequence":"additional","affiliation":[{"name":"Uppsala Clinical Research Center (UCR), Uppsala University, Uppsala, Sweden"},{"name":"Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Tarka","sequence":"additional","affiliation":[{"name":"Former Employee of Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe Gabriel","family":"Steg","sequence":"additional","affiliation":[{"name":"FACT (French Alliance for Cardiovascular Trials), Paris, France"},{"name":"DHU FIRE, Universit\u00e9 Paris\u2010Diderot, Sorbonne Paris\u2010Cit\u00e9, Paris, France"},{"name":"H\u00f4pital Bichat, INSERUM U\u20101148, Paris, France"},{"name":"NHLI, ICMS, Imperial College, Royal Brompton Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph A. 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