{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:06:43Z","timestamp":1792699603338,"version":"4.5.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,5,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Statin therapy reduces the risk of cardiovascular events in patients with obstructive coronary artery disease. The aim of the present study was to determine the effects of statins on the prognosis of patients with coronary vasospastic angina (\n              <jats:styled-content style=\"fixed-case\">VSA<\/jats:styled-content>\n              ) free of significant atherosclerotic stenosis.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              After exclusion of 475 from 1877 consecutive patients who underwent an acetylcholine\u2010provocation test between January 1991 and December 2010, data of 640\n              <jats:styled-content style=\"fixed-case\">VSA<\/jats:styled-content>\n              patients without significant organic stenosis of the remaining 1402 were analyzed retrospectively. Propensity score matching was performed to reduce the effect of treatment\u2010selection bias and possible confounders. The primary endpoint was major adverse cardiac events (\n              <jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content>\n              ), including cardiac death, nonfatal myocardial infarction, and unstable angina. Among the study population, dyslipidemia on admission was identified in 160 of 168 (95.2%) patients of the statin group compared with only 125 of 472 (26.5%) of the no\u2010statin group. Of the 640 patients, 24 (3.8%) developed\n              <jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content>\n              . Multivariate Cox hazard regression analysis identified statin therapy as a significant negative predictor of\n              <jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content>\n              (hazard ratio, 0.11; 95% CI, 0.02\u20130.84;\n              <jats:italic>P<\/jats:italic>\n              =0.033). In the propensity\u2010score matched cohorts (n=128 each), Kaplan\u2013Meier survival curve showed a better 5\u2010year\n              <jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content>\n              \u2010free survival rate for patients of the statin group compared to the no\u2010statin group (100% vs 91.7%, respectively;\n              <jats:italic>P<\/jats:italic>\n              =0.002).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Statin therapy correlated with a lower rate of cardiovascular events in\n              <jats:styled-content style=\"fixed-case\">VSA<\/jats:styled-content>\n              patients free of significant organic stenosis. Statins seems to improve the prognosis of\n              <jats:styled-content style=\"fixed-case\">VSA<\/jats:styled-content>\n              patients free of significant organic stenosis.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.003426","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T16:25:46Z","timestamp":1464020746000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":59,"title":["Impact of Statin Therapy on Clinical Outcome in Patients With Coronary Spasm"],"prefix":"10.1161","volume":"5","author":[{"given":"Masanobu","family":"Ishii","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Kaikita","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular 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