{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:20:57Z","timestamp":1790011257065,"version":"4.0.1"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Asthma is a heterogeneous syndrome with different clinical subtypes that is associated with an increased risk for cardiovascular disease (CVD). We hypothesized that the late\u2010onset subtype of asthma is associated with a higher risk of incident CVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Participants from the Wisconsin Sleep Cohort free of CVD at baseline were followed for a mean (SD) of 13.9 (5.9) years for development of CVD (myocardial infarction, angina, stroke, coronary revascularization, heart failure, or CVD death). Late\u2010onset asthma was defined as physician\u2010diagnosed asthma at age \u226518\u00a0years. Multivariable Cox regression models adjusted for age, sex, and CVD risk factors were used to assess associations of late\u2010onset asthma and incident CVD. The 1269 participants were 47.3 (8.0) years old; 166 participants had asthma (111 late\u2010onset, 55 early\u2010onset). Participants with late\u2010onset asthma compared to nonasthmatics were more likely to be female (67% versus 44%) and to have a higher body\u2010mass index (32.2 versus 29.4\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.05). Mean age of asthma diagnosis in the late\u2010onset group was 39.5 (9.6) years versus 8.9 (5.7) years in the early\u2010onset group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001). Late\u2010onset asthmatics had a higher adjusted risk of incident CVD than nonasthmatics (hazard ratio 1.57, 95% CI 1.01\u20132.45,\n                      <jats:italic>P<\/jats:italic>\n                      =0.045). There was no interaction between body\u2010mass index and age of asthma diagnosis on incident CVD (\n                      <jats:italic>P<\/jats:italic>\n                      =0.83).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In a large cohort study of adults followed prospectively for over a decade, late\u2010onset asthmatics had an increased risk of incident CVD events that persisted after adjustment for age, sex, and CVD risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.116.003448","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T23:08:59Z","timestamp":1472080139000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Late\u2010Onset Asthma Predicts Cardiovascular Disease Events: The Wisconsin Sleep Cohort"],"prefix":"10.1161","volume":"5","author":[{"given":"Matthew C.","family":"Tattersall","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi H.","family":"Barnet","sequence":"additional","affiliation":[{"name":"Department of Population Health, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia E.","family":"Korcarz","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika W.","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Population Health, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Peppard","sequence":"additional","affiliation":[{"name":"Department of Population Health, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Stein","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","first-page":"1","article-title":"Trends in asthma prevalence, health care use, and mortality in the United States, 2001\u20132010","volume":"94","author":"Akinbami LJ","year":"2012","unstructured":"Akinbami LJ, Moorman JE, Bailey C, Zahran HS, King M, Johnson CA, Liu X. Trends in asthma prevalence, health care use, and mortality in the United States, 2001\u20132010. NCHS Data Brief. 2012;94:1\u20138.","journal-title":"NCHS Data Brief"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000441139.02102.80"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043430"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394300-2.00002-8"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.242716099"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807646"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003233421202"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0548-7"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000054612.26458.B2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704033361401"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-013-0168-6"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.302191"},{"key":"e_1_3_3_14_2","first-page":"129","article-title":"Cardiovascular risk and dyslipidemia management in HIV\u2010infected patients","volume":"20","author":"Stein JH","year":"2012","unstructured":"Stein JH. Cardiovascular risk and dyslipidemia management in HIV\u2010infected patients. Top Antivir Med. 2012;20:129\u2013133; quiz 123\u2013124.","journal-title":"Top Antivir Med"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050203"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305452"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws181"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyh081"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.026484"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.12.024"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.02.017"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/02770909609077762"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.21.2521"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2678"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/25.3.617"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281704"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005113421901"},{"key":"e_1_3_3_28_2","first-page":"1071","article-title":"Sleep disordered breathing and mortality: eighteen\u2010year follow\u2010up of the Wisconsin sleep cohort","volume":"31","author":"Young T","year":"2008","unstructured":"Young T, Finn L, Peppard PE, Szklo\u2010Coxe M, Austin D, Nieto FJ, Stubbs R, Hla KM. Sleep disordered breathing and mortality: eighteen\u2010year follow\u2010up of the Wisconsin sleep cohort. Sleep. 2008;31:1071\u20131078.","journal-title":"Sleep"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.17822"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4654"},{"key":"e_1_3_3_31_2","unstructured":"Rechtscahaffen A Kales A. A manual of standardized terminology techniques and scoring system for sleep stages of human subjects. National Institutes of Health publication no. 204; 1968."},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.07.011"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2867"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00007112"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113434"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.02.038"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.07.002"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00077012"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.23.2810"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn464"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.3.8087330"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2014.09.016"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.6.1952"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000037220.00065.0D"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2010.03.017"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.03.019"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.116.003448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T06:06:15Z","timestamp":1715580375000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.116.003448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1161\/JAHA.116.003448"],"URL":"https:\/\/doi.org\/10.1161\/jaha.116.003448","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726673508.793525923","asserted-by":"object"}]},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"2016-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e003448"}}