{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:24:30Z","timestamp":1773285870588,"version":"3.50.1"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,7,6]]},"abstract":"\n Background<\/jats:title>\n \n We previously have shown that glibenclamide (\n GBC<\/jats:styled-content>\n ), a sulfonylurea receptor 1\u2013transient receptor potential M4 (\n SUR<\/jats:styled-content>\n 1\u2010\n TRPM<\/jats:styled-content>\n 4) channel inhibitor, improves survival and neurological outcome after asphyxial cardiac arrest and cardiopulmonary resuscitation (\n ACA<\/jats:styled-content>\n \/\n CPR<\/jats:styled-content>\n ). Here, we further compare the efficacy of\n GBC<\/jats:styled-content>\n with target temperature management (\n TTM<\/jats:styled-content>\n ) and determine whether the efficacy of\n GBC<\/jats:styled-content>\n is affected by\n TTM<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Male Sprague\u2010Dawley rats (n=213) subjected to 10\u2010minute\n ACA<\/jats:styled-content>\n \/\n CPR<\/jats:styled-content>\n were randomized to 4 groups after return of spontaneous circulation (\n ROSC<\/jats:styled-content>\n ): normothermia control (\n NT<\/jats:styled-content>\n );\n GBC<\/jats:styled-content>\n ;\n TTM<\/jats:styled-content>\n ; and\n TTM<\/jats:styled-content>\n +\n GBC<\/jats:styled-content>\n . Survival, neurodeficit scores, histological injury, as well as the expressions of\n SUR<\/jats:styled-content>\n 1 and\n TRPM<\/jats:styled-content>\n 4 were evaluated. The 7\u2010day survival rate was 34.4% (11 of 32) in the\n NT<\/jats:styled-content>\n group, 65% (13 of 20) in the\n GBC<\/jats:styled-content>\n group, 50% (10 of 20) in the\n TTM<\/jats:styled-content>\n group, and 70% (14 of 20) in the\n TTM<\/jats:styled-content>\n +\n GBC<\/jats:styled-content>\n group. Rats that received either\n GBC<\/jats:styled-content>\n ,\n TTM<\/jats:styled-content>\n alone, or in combination showed less neurological deficit than\n NT<\/jats:styled-content>\n control at 24, 48, and 72\u00a0hours and 7\u00a0days after\n ROSC<\/jats:styled-content>\n . Moreover,\n TTM<\/jats:styled-content>\n or\n GBC<\/jats:styled-content>\n ameliorated neuronal degeneration and glial activation in the hippocampal\n CA<\/jats:styled-content>\n 1 region with similar efficacy, whereas the combination of them had a trend toward better effect. The subunits of\n SUR<\/jats:styled-content>\n 1\u2010\n TRPM<\/jats:styled-content>\n 4 heterodimers were both strongly upregulated after\n ACA<\/jats:styled-content>\n \/\n CPR<\/jats:styled-content>\n and expressed in multiple types of brain cells, but partly suppressed by\n TTM<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n GBC<\/jats:styled-content>\n is comparable to\n TTM<\/jats:styled-content>\n in improving survival and neurological outcome after\n ACA<\/jats:styled-content>\n \/\n CPR<\/jats:styled-content>\n . When\n GBC<\/jats:styled-content>\n is given along with\n TTM<\/jats:styled-content>\n , less histological injury tended to be achieved.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.003465","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T05:57:19Z","timestamp":1468475839000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Glibenclamide Is Comparable to Target Temperature Management in Improving Survival and Neurological Outcome After Asphyxial Cardiac Arrest in Rats"],"prefix":"10.1161","volume":"5","author":[{"given":"Kaibin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanfang Hospital, Southern Medical 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