{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:42:59Z","timestamp":1783341779054,"version":"3.54.6"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,7,6]]},"abstract":"\n Background<\/jats:title>\n \n There is limited evidence of long\u2010term impact of right ventricular pacing on left ventricular (\n LV<\/jats:styled-content>\n ) systolic function in pacemaker recipients with preserved\n LV<\/jats:styled-content>\n ejection fraction (\n LVEF<\/jats:styled-content>\n ). The objective of the study was to evaluate the outcome and echocardiographic course of baseline preserved\n LVEF<\/jats:styled-content>\n in a large cohort of pacemaker recipients with respect to pacing indication and degree of right ventricular pacing.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We enrolled 991 patients (73\u00b110\u00a0years, 54% male) with baseline normal (>55%)\n LVEF<\/jats:styled-content>\n (n=791) or mildly reduced (41\u201355%)\n LVEF<\/jats:styled-content>\n (n=200) who had paired echocardiographic data on\n LV<\/jats:styled-content>\n systolic function recorded at implantation and last follow\u2010up. According to pacing indication, patients were divided into atrioventricular block group A (n=500) and sinus node disease group B (n=491). Main outcome measures were all\u2010cause mortality and deterioration of\n LV<\/jats:styled-content>\n function \u22652\n LVEF<\/jats:styled-content>\n categories at last follow\u2010up. Patients were followed for an average of 44\u00a0months. Death from any cause occurred in 166 (17%), and deterioration of\n LV<\/jats:styled-content>\n function \u22652\n LVEF<\/jats:styled-content>\n categories in 56 (6%) patients. There was no significant difference in outcome between group A and group B either in patients with normal\n LVEF<\/jats:styled-content>\n or in those with mildly reduced\n LVEF<\/jats:styled-content>\n . Mean percentage of right ventricular pacing was not predictive of outcome.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In a large cohort of pacemaker recipients with predominantly normal\n LVEF<\/jats:styled-content>\n , clinically relevant\n LV<\/jats:styled-content>\n dysfunction develops rather infrequently. No significant difference in all\u2010cause mortality and development of severe\n LV<\/jats:styled-content>\n dysfunction is observed between patients with atrioventricular block and sinus node disease. Accordingly, de novo biventricular pacing cannot be recommended for patients with preserved\n LVEF<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.003485","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T01:34:18Z","timestamp":1469151258000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["Long\u2010Term Impact of Right Ventricular Pacing on Left Ventricular Systolic Function in Pacemaker Recipients With Preserved Ejection Fraction: Results From a Large Single\u2010Center Registry"],"prefix":"10.1161","volume":"5","author":[{"given":"Micaela","family":"Ebert","sequence":"first","affiliation":[{"name":"Department of Electrophysiology, Heart Center\u2013University of Leipzig, Germany"},{"name":"Department of Electrophysiology, University Heart Center Freiburg\u2013Bad Krozingen, 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