{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T09:22:18Z","timestamp":1792574538214,"version":"4.5.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,5,6]]},"abstract":"\n Background<\/jats:title>\n \n Klinefelter syndrome (\n KS<\/jats:styled-content>\n ) is the most common sex chromosome disorder. The genetic background is the extra X chromosome. Venous thromboembolism (\n VTE<\/jats:styled-content>\n ) has been observed among\n KS<\/jats:styled-content>\n patients. The aim of the present study was to examine whether\n KS<\/jats:styled-content>\n is associated with\n VTE<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We followed up all hospital in\u2010 and outpatients (N=1085) in Sweden with a diagnosis of\n KS<\/jats:styled-content>\n between January 1, 1969, and December 31, 2010, for diagnosis of\n VTE<\/jats:styled-content>\n . The reference population was the total male populace of Sweden. We calculated standardized incidence ratios for\n VTE<\/jats:styled-content>\n , adjusted for age, sex, education, time period, and region of residence. The standardized incidence ratio for\n KS<\/jats:styled-content>\n was 6.43 (95% CI 5.15\u20137.93), with the highest ratio observed at young age. The standardized incidence ratios for\n VTE<\/jats:styled-content>\n were 12.10 (95%\n CI<\/jats:styled-content>\n 6.22\u201321.21) before age 30\u00a0years, 11.00 (95% CI 7.86\u201314.99) between ages 30 and 49\u00a0years, 4.83 (95% CI 3.23\u20136.95) between ages 50 and 69 years, and 2.07 (95% CI 0.74\u20134.53) for ages \u226570\u00a0years. The cumulative incidence of\n VTE<\/jats:styled-content>\n for\n KS<\/jats:styled-content>\n patients was 8.6% at age 50\u00a0years and 20.8% at age 70\u00a0years.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n KS is associated with high risk of VTE. KS could be considered a genetic hypercoagulable state. This has clinical implications for the prevention and diagnosis of\n VTE<\/jats:styled-content>\n among patients with KS.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.003567","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T14:19:09Z","timestamp":1464013149000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["High Risk of Venous Thromboembolism in Klinefelter Syndrome"],"prefix":"10.1161","volume":"5","author":[{"given":"Bengt","family":"Z\u00f6ller","sequence":"first","affiliation":[{"name":"Center for Primary Health Care Research, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguang","family":"Ji","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2382"},{"key":"e_1_3_4_3_2","first-page":"347","article-title":"Klinefelter syndrome: the commonest form of hypogonadism, but often overlooked or untreated","volume":"110","author":"Nieschlag E","year":"2013","unstructured":"Nieschlag E. 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