{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:42:10Z","timestamp":1793072530765,"version":"4.5.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,2,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Excess levels of serum acylcarnitines, which are intermediate products in metabolism, have been observed in metabolic diseases such as type 2 diabetes mellitus. However, it is not known whether acylcarnitines may prospectively predict risk of cardiovascular death or acute myocardial infarction in patients with stable angina pectoris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      This study included 4164 patients (median age, 62\u00a0years; 72% men). Baseline serum acetyl\u2010, octanoyl\u2010, palmitoyl\u2010, propionyl\u2010, and (iso)valerylcarnitine were measured using liquid chromatography\/tandem mass spectrometry. Hazard ratios (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      s) and 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      s for quartile 4 versus quartile 1 are reported. The multivariable model included age, sex, body mass index, fasting status, current smoking, diabetes mellitus, apolipoprotein A1, apolipoprotein B, creatinine, left ventricular ejection fraction, extent of coronary artery disease, study center, and intervention with folic acid or vitamin B6. During median 10.2\u00a0years of follow\u2010up, 10.0% of the patients died of cardiovascular disease and 12.8% suffered a fatal or nonfatal acute myocardial infarction. Higher levels of the even\u2010chained acetyl\u2010, octanoyl\u2010, and palmitoyl\u2010carnitines were significantly associated with elevated risk of cardiovascular death, also after multivariable adjustments (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      [95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ]: 1.52 [1.12, 2.06];\n                      <jats:italic>P<\/jats:italic>\n                      =0.007; 1.73 [1.23, 2.44];\n                      <jats:italic>P<\/jats:italic>\n                      =0.002; and 1.61 [1.18, 2.21];\n                      <jats:italic>P<\/jats:italic>\n                      =0.003, respectively), whereas their associations with acute myocardial infarction were less consistent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among patients with suspected stable angina pectoris, elevated serum even\u2010chained acylcarnitines were associated with increased risk of cardiovascular death and, to a lesser degree with acute myocardial infarction, independent of traditional risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n                      :\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      . Unique identifier:\n                      <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n                      00354081.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.116.003620","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T20:10:44Z","timestamp":1486152644000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":95,"title":["Serum Acylcarnitines and Risk of Cardiovascular Death and Acute Myocardial Infarction in Patients With Stable Angina Pectoris"],"prefix":"10.1161","volume":"6","author":[{"given":"Elin","family":"Strand","sequence":"first","affiliation":[{"name":"Department of Clinical Science, University of Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva R.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gard F. 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