{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:43:19Z","timestamp":1774525399349,"version":"3.50.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,8,8]]},"abstract":"<jats:sec xml:lang=\"en\"><jats:title>Background<\/jats:title><jats:p xml:lang=\"en\">Cardiac arrhythmias and sudden cardiac death are more frequent in patients with obstructive sleep apnea (<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>).<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>is associated with<jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>prolongation, and<jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>prolongation is an independent risk factor for sudden cardiac death. Because<jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>prolongation can be mediated by potassium channel loss of function, we tested whether<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>or continuous positive airway pressure therapy altered<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>expression of circulating white blood cell potassium channels.<\/jats:p><\/jats:sec><jats:sec xml:lang=\"en\"><jats:title>Methods and Results<\/jats:title><jats:p xml:lang=\"en\">In total, 28 patients with OSA newly diagnosed by polysomnogram and 6 participants without<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>were enrolled. Potassium channel levels in white blood cells at baseline and at a 4\u2010week follow\u2010up visit were compared. There was a significant inverse correlation between the severity of the<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>stratified by apnea\u2013hypopnea index and<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>expression of the main potassium channels assessed:<jats:styled-content style=\"fixed-case\">KCNQ<\/jats:styled-content>1 (<jats:italic>r<\/jats:italic>=\u22120.486,<jats:italic>P<\/jats:italic>=0.007),<jats:styled-content style=\"fixed-case\">KCNH<\/jats:styled-content>2 (<jats:italic>r<\/jats:italic>=\u22120.437,<jats:italic>P<\/jats:italic>=0.016),<jats:styled-content style=\"fixed-case\">KCNE<\/jats:styled-content>1 (<jats:italic>r<\/jats:italic>=\u22120.567,<jats:italic>P<\/jats:italic>=0.001),<jats:styled-content style=\"fixed-case\">KCNJ<\/jats:styled-content>2 (<jats:italic>r<\/jats:italic>=\u22120.442,<jats:italic>P<\/jats:italic>=0.015), and<jats:styled-content style=\"fixed-case\">KCNA<\/jats:styled-content>5 (<jats:italic>r<\/jats:italic>=\u22120.468,<jats:italic>P<\/jats:italic>=0.009). In addition,<jats:styled-content style=\"fixed-case\">KCNQ<\/jats:styled-content>1,<jats:styled-content style=\"fixed-case\">KCNH<\/jats:styled-content>2, and<jats:styled-content style=\"fixed-case\">KCNE<\/jats:styled-content>1 inversely correlated with the oxygen desaturation index 4. After 4\u00a0weeks of continuous positive airway pressure therapy, circulating<jats:styled-content style=\"fixed-case\">KCNQ<\/jats:styled-content>1 and<jats:styled-content style=\"fixed-case\">KCNJ<\/jats:styled-content>2 were increased 1.4\u00b10.4\u2010fold (<jats:italic>P<\/jats:italic>=0.040) and 2.1\u00b11.4\u2010fold (<jats:italic>P<\/jats:italic>=0.046) in the moderate<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>group. Compared with patients with mild or moderate<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>, patients with severe<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>had a persistently higher apnea\u2013hypopnea index (mild 2.0\u00b11.8, moderate 1.0\u00b10.9, severe 5.8\u00b15.6;<jats:italic>P<\/jats:italic>=0.015), perhaps explaining why the potassium channel changes were not seen in the severe<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>group.<\/jats:p><\/jats:sec><jats:sec xml:lang=\"en\"><jats:title>Conclusions<\/jats:title><jats:p xml:lang=\"en\">The<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>expression of most potassium channels inversely correlates with the severity of<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>and hypoxemia. Continuous positive airway pressure therapy improves circulating<jats:styled-content style=\"fixed-case\">KCNQ<\/jats:styled-content>1 and<jats:styled-content style=\"fixed-case\">KCNJ<\/jats:styled-content>2 in patients with moderate<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1161\/jaha.116.003666","type":"journal-article","created":{"date-parts":[[2016,8,20]],"date-time":"2016-08-20T03:19:02Z","timestamp":1471663142000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Obstructive Sleep Apnea and Circulating Potassium Channel Levels"],"prefix":"10.1161","volume":"5","author":[{"given":"Ning","family":"Jiang","sequence":"first","affiliation":[{"name":"Lifespan Cardiovascular Institute, Brown University, Providence, RI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Lifespan Cardiovascular Institute, Brown University, Providence, RI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharati","family":"Prasad","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy","family":"Doumit","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangbin","family":"Shi","sequence":"additional","affiliation":[{"name":"Lifespan Cardiovascular Institute, Brown University, Providence, RI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafiz","family":"Imran","sequence":"additional","affiliation":[{"name":"Lifespan Cardiovascular Institute, Brown University, Providence, RI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahaa","family":"Kaseer","sequence":"additional","affiliation":[{"name":"Lifespan Cardiovascular Institute, Brown University, Providence, RI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Millman","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital, Brown University, Providence, RI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Samuel C.","family":"Dudley","sequence":"additional","affiliation":[{"name":"Lifespan Cardiovascular Institute, Brown University, Providence, RI"},{"name":"The Providence VA, Providence, RI"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200709-155MG"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.080"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.3600"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.067"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.797035"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.6.1888"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.4.346"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-012-2457-y"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2005.00188.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2916"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs073"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.4.10"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.10.1178"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb11296.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.931184"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2004.10.008"},{"key":"e_1_3_3_18_2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0022-3565(25)21354-4","article-title":"Activation of ATP\u2010sensitive ourward K+ current by nicorandil (2\u2010nicotinamideoethyl nitrate) in isolated ventricular myocytes","volume":"250","author":"Hiraoka M","year":"1989","unstructured":"Hiraoka M, Fan Z. Activation of ATP\u2010sensitive ourward K+ current by nicorandil (2\u2010nicotinamideoethyl nitrate) in isolated ventricular myocytes. J Pharmacol Exp Ther. 1989;250:278\u2013285.","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.588"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e318187c83a"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/22.5.667"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)90424-2"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.7.915"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-013-1006-z"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0311"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.13.8581"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2008.05.002"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.116.003666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T10:59:29Z","timestamp":1749553169000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.116.003666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,8]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8,8]]}},"alternative-id":["10.1161\/JAHA.116.003666"],"URL":"https:\/\/doi.org\/10.1161\/jaha.116.003666","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,8]]},"assertion":[{"value":"2016-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e003666"}}