{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:12:09Z","timestamp":1792419129877,"version":"4.5.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,9]]},"abstract":"\n Background<\/jats:title>\n \n Experimental studies demonstrated that glutathione peroxidase 3 (\n GP<\/jats:styled-content>\n x3), an antioxidant enzyme that catabolizes hydrogen peroxide, protects against thrombosis. Little is known about its role in cardiovascular disease.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n A prospective cohort study was conducted in 909 atrial fibrillation patients. Serum activities of\n GP<\/jats:styled-content>\n x3, superoxide dismutase (\n SOD<\/jats:styled-content>\n ), and catalase were measured at baseline to assess the risk of cardiovascular events during a mean follow\u2010up of 43.4\u00a0months (3291 person\u2010years). Serum Nox2 and urinary excretion of 11\u2010deydro\u2010thromboxane B\n 2<\/jats:sub>\n were also measured. During follow\u2010up 160 cardiovascular events occurred (4.9%\/year). Significantly lower values of\n GP<\/jats:styled-content>\n x3 (\n P<\/jats:italic>\n <0.001) and\n SOD<\/jats:styled-content>\n (\n P<\/jats:italic>\n =0.037) were detected in patients with, compared to those without, cardiovascular events. A lower survival rate was observed in patients with\n GP<\/jats:styled-content>\n x3 (\n P<\/jats:italic>\n <0.001) and\n SOD<\/jats:styled-content>\n (\n P<\/jats:italic>\n =0.010) activities below the median, as compared to those above. In a fully adjusted Cox regression model,\n GP<\/jats:styled-content>\n x3 was the only antioxidant enzyme predictor of cardiovascular events (hazard ratio 0.647, 95% confidence interval 0.524\u20100.798,\n P<\/jats:italic>\n <0.001).\n GP<\/jats:styled-content>\n x3 was inversely associated with urinary 11\u2010dehydro\u2010thromboxane B\n 2<\/jats:sub>\n (B \u22120.337,\n P<\/jats:italic>\n <0.001) and serum Nox2 (B: \u22120.423,\n P<\/jats:italic>\n <0.001).\n GP<\/jats:styled-content>\n x3 activity progressively decreased with decades of age (\n P<\/jats:italic>\n <0.001), with a progressive reduction in people aged \u226570\u00a0years.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This study provides evidence that a low antioxidant status, as depicted by reduced levels of\n GP<\/jats:styled-content>\n x3, increases the risk of cardiovascular events in patients with atrial fibrillation. The age\u2010related decline of\n GP<\/jats:styled-content>\n x3 may represent a mechanism for the enhanced cardiovascular risk in the elderly population.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.003682","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T02:18:28Z","timestamp":1473387508000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":63,"title":["Aging\u2010Related Decline of Glutathione Peroxidase 3 and Risk of Cardiovascular Events in Patients With Atrial Fibrillation"],"prefix":"10.1161","volume":"5","author":[{"given":"Daniele","family":"Pastori","sequence":"first","affiliation":[{"name":"I Clinica Medica, Atherothrombosis Centre, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Pignatelli","sequence":"additional","affiliation":[{"name":"I Clinica Medica, Atherothrombosis Centre, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Farcomeni","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Menichelli","sequence":"additional","affiliation":[{"name":"I Clinica Medica, Atherothrombosis Centre, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Nocella","sequence":"additional","affiliation":[{"name":"I Clinica Medica, Atherothrombosis Centre, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Carnevale","sequence":"additional","affiliation":[{"name":"I Clinica Medica, Atherothrombosis Centre, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Violi","sequence":"additional","affiliation":[{"name":"I Clinica Medica, Atherothrombosis Centre, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(15)31026-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5111"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4891"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030535"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-07-0571"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut012"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.014"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3586"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.07.015"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328364ca4c"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1093\/eurheartj\/eht108","article-title":"ESC guidelines on diabetes, pre\u2010diabetes, and cardiovascular diseases developed in collaboration with the EASD: the task force on diabetes, pre\u2010diabetes, and cardiovascular diseases of the European society of cardiology (ESC) and developed in collaboration with the European association for the study of diabetes (EASD)","volume":"34","author":"Ryd\u00e9n L","year":"2013","unstructured":"Ryd\u00e9n L, Grant PJ, Anker SD, Berne C, Cosentino F, Danchin N, Deaton C, Escaned J, Hammes HP, Huikuri H, Marre M, Marx N, Mellbin L, Ostergren J, Patrono C, Seferovic P, Uva MS, Taskinen MR, Tendera M, Tuomilehto J, Valensi P, Zamorano JL; 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