{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:03:25Z","timestamp":1791558205458,"version":"4.3.4"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,8,8]]},"abstract":"\n Background<\/jats:title>\n \n Urinary 11\u2010dehydro\u2010thromboxane (\n TX<\/jats:styled-content>\n )B\n 2<\/jats:sub>\n has been described as a potential predictive biomarker of major adverse cardiovascular events (\n MACE<\/jats:styled-content>\n s) in high cardiac risk patients. This part of\n LTIMI<\/jats:styled-content>\n (Leukotrienes and Thromboxane In Myocardial Infarction) study aimed to evaluate the relationship between 11\u2010dehydro\u2010\n TXB<\/jats:styled-content>\n 2<\/jats:sub>\n and\n MACE<\/jats:styled-content>\n s in patients with acute myocardial infarction (\n AMI<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n LTIMI<\/jats:styled-content>\n was an observational, prospective study in 180 consecutive patients with\n AMI<\/jats:styled-content>\n type 1 referred for primary percutaneous coronary intervention. On admission and at follow\u2010up visits (1 month, 1 year), 11\u2010dehydro\u2010\n TXB<\/jats:styled-content>\n 2<\/jats:sub>\n was measured in urinary samples by using high\u2010performance liquid chromatography\u2013tandem mass spectrometry. The primary outcome was occurrence of composite\n MACE<\/jats:styled-content>\n s during 1\u2010year after\n AMI<\/jats:styled-content>\n . Left ventricular ejection fraction was assessed in echocardiography on admission and at 1\u2010year follow\u2010up. Analyses of 11\u2010dehydro\u2010\n TXB<\/jats:styled-content>\n 2<\/jats:sub>\n (pg\/mg creatinine) were performed on log\u2010transformed data and expressed as median with\n IQR<\/jats:styled-content>\n (Q1\u2013Q3). 11\u2010Dehydro\u2010\n TXB<\/jats:styled-content>\n 2<\/jats:sub>\n level on admission was 7.39 (6.85\u20138.01) and decreased at 1 month (6.73, 6.27\u20137.12;\n P<\/jats:italic>\n <0.001) and 1\u2010year follow\u2010up (6.37, 5.91\u20136.94;\n P<\/jats:italic>\n <0.001). In univariate analysis, baseline 11\u2010dehydro\u2010\n TXB<\/jats:styled-content>\n 2<\/jats:sub>\n was higher in patients with\n MACE<\/jats:styled-content>\n s (n=60; 7.73, 7.07\u20138.60) compared with those without\n MACE<\/jats:styled-content>\n s (n=119; 7.28, 6.68\u20137.79;\n P<\/jats:italic>\n =0.002). In multivariate regression model, 11\u2010dehydro\u2010\n TXB<\/jats:styled-content>\n 2<\/jats:sub>\n and 3 other variables (diabetes, multivessel disease, and left ventricular ejection fraction) were found to be best 1\u2010year cumulative\n MACE<\/jats:styled-content>\n predictors with odds ratio for 11\u2010dehydro\u2010\n TXB<\/jats:styled-content>\n 2<\/jats:sub>\n of 1.58 (95%\n CI<\/jats:styled-content>\n 1.095\u20132.33;\n P<\/jats:italic>\n =0.017) and area under the curve (in receiver operating characteristic analysis of 0.8). Baseline 11\u2010dehydro\u2010\n TXB<\/jats:styled-content>\n 2<\/jats:sub>\n negatively correlated with both left ventricular ejection fraction on admission (\n R<\/jats:italic>\n =\u22120.21;\n P<\/jats:italic>\n =0.006) and after 1 year (\n R<\/jats:italic>\n =\u22120.346;\n P<\/jats:italic>\n <0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n 11\u2010Dehydro\u2010\n TXB<\/jats:styled-content>\n 2<\/jats:sub>\n predicts 1\u2010year cumulative\n MACE<\/jats:styled-content>\n s in\n AMI<\/jats:styled-content>\n patients and provides prognostic information on the left ventricular performance.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.003702","type":"journal-article","created":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T22:29:04Z","timestamp":1470090544000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Urinary 11\u2010Dehydro\u2010Thromboxane B\n 2<\/sub>\n as a Predictor of Acute Myocardial Infarction Outcomes: Results of Leukotrienes and Thromboxane In Myocardial Infarction (LTIMI) Study"],"prefix":"10.1161","volume":"5","author":[{"given":"Wojciech","family":"Szczeklik","sequence":"first","affiliation":[{"name":"Department of Medicine, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edyta","family":"Stod\u00f3\u0142kiewicz","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Rzeszutko","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Tomala","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Chrustowicz","sequence":"additional","affiliation":[{"name":"Noninvasive Cardiovascular Laboratory, John Paul II Hospital, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"\u017bmudka","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Sanak","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1102-1227"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052717"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03184.x"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12026"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)68855-1"},{"key":"e_1_3_5_7_2","first-page":"I12","article-title":"Biosynthesis and pharmacological modulation of thromboxane in humans","volume":"81","author":"Patrono C","year":"1990","unstructured":"Patrono C. 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