{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T09:58:56Z","timestamp":1781517536715,"version":"3.54.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,10,26]]},"abstract":"\n Background<\/jats:title>\n \n Coronary heart disease is a significant cause of morbidity and mortality in stroke patients. The coronary artery calcium score (\n CACS<\/jats:styled-content>\n ) has emerged as a robust and noninvasive predictor of coronary events. We assessed the predictive ability of\n CACS<\/jats:styled-content>\n to identify stroke patients with severe (\u226550%) occult coronary artery stenosis in a stroke\/transient ischemic attack population, in addition to the\n PRECORIS<\/jats:styled-content>\n score, based on Framingham Risk Score and presence of cervicocephalic artery stenosis, which was derived and validated for that purpose.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We enrolled consecutive patients aged 45 to 75\u00a0years referred to our stroke unit with noncardioembolic ischemic stroke or transient ischemic attack, and no prior history of coronary disease. The presence of coronary stenosis was assessed with 64\u2010section computed tomography coronary angiography, and all patients had a detailed etiological work\u2010up.\n CACS<\/jats:styled-content>\n was determined from computed tomography measurement using the Agatson score. The predictive value of\n CACS<\/jats:styled-content>\n was assessed by logistic regression and reclassification method. Among 300 patients included in the study, 274 had computed tomography coronary angiography. Fifty patients (18%) had at least 1 coronary artery stenosis \u226550%. In multivariable analysis, after adjustment for the\n PRECORIS<\/jats:styled-content>\n score,\n CACS<\/jats:styled-content>\n was strongly associated with the presence of occult coronary artery stenosis (odds ratio=14.8 [1.8\u2013120.3] for\n CACS<\/jats:styled-content>\n [1\u2013100] and 70.9 [8.9\u2013562.0] for\n CACS<\/jats:styled-content>\n >100). When\n CACS<\/jats:styled-content>\n was added to the standard model, model fit was improved (\n P<\/jats:italic>\n <0.001), Net Reclassification Improvement was 28.2% (\n P<\/jats:italic>\n <0.001), and Integrated Discrimination Index was 18.2% (\n P<\/jats:italic>\n <0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In stroke\/transient ischemic attack patients,\n CACS<\/jats:styled-content>\n improves the prediction of occult coronary stenosis beyond classical risk factors.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.003770","type":"journal-article","created":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T01:11:58Z","timestamp":1477962718000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Coronary Artery Calcium Score Improves the Prediction of Occult Coronary Artery Stenosis in Ischemic Stroke Patients"],"prefix":"10.1161","volume":"5","author":[{"given":"Ysoline","family":"Beigneux","sequence":"first","affiliation":[{"name":"Department of Neurology, Centre Hospitalier Sainte\u2010Anne, Universit\u00e9 Paris Descartes DHU Neurovasc Sorbonne Paris Cit\u00e9, INSERM U894, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Sablayrolles","sequence":"additional","affiliation":[{"name":"Department of Radiology, Centre Cardiologique du Nord, Saint\u2010Denis, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Varenne","sequence":"additional","affiliation":[{"name":"Department of Cardiology, H\u00f4pital Cochin, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Mas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre Hospitalier Sainte\u2010Anne, Universit\u00e9 Paris Descartes DHU Neurovasc Sorbonne Paris Cit\u00e9, INSERM U894, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Calvet","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre Hospitalier Sainte\u2010Anne, Universit\u00e9 Paris Descartes DHU Neurovasc Sorbonne Paris Cit\u00e9, INSERM U894, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.921072"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.02.005"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.906958"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.584086"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000334980"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.72.404"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003414"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12015"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.461"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.9624"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072100"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.02.006"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.01.056"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018524"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182051b4c"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.116.003770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:21:50Z","timestamp":1715595710000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.116.003770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,26]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,10,26]]}},"alternative-id":["10.1161\/JAHA.116.003770"],"URL":"https:\/\/doi.org\/10.1161\/jaha.116.003770","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,26]]},"assertion":[{"value":"2016-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e003770"}}