{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:29:11Z","timestamp":1753889351801,"version":"3.41.2"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,10,26]]},"abstract":"\n Background<\/jats:title>\n \n We examined all\u2010cause mortality and long\u2010term thromboembolic risk (ischemic stroke, transient ischemic attack, systemic thromboembolism) in patients with and without familial atrial fibrillation (\n AF<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Using Danish nationwide registry data, we identified all patients diagnosed with\n AF<\/jats:styled-content>\n (1995\u20132012) and divided them into those with familial\n AF<\/jats:styled-content>\n (having a first\u2010degree family member with a prior\n AF<\/jats:styled-content>\n admission) and those with nonfamilial\n AF<\/jats:styled-content>\n . We paired those with and without familial\n AF<\/jats:styled-content>\n according to age, year of\n AF<\/jats:styled-content>\n diagnosis, and sex in a 1:1 match. Using cumulative incidence and multivariable Cox models, we examined the risk of long\u2010term outcomes. We identified 8658\n AF<\/jats:styled-content>\n patients (4329 matched pairs) with and without familial\n AF<\/jats:styled-content>\n . The median age was 50\u00a0years (interquartile range 43\u201354 years), and 21.4% were women. Compared with nonfamilial\n AF<\/jats:styled-content>\n patients, those with familial\n AF<\/jats:styled-content>\n had slightly less comorbid illness but similar overall\n CHA<\/jats:styled-content>\n 2<\/jats:sub>\n DS<\/jats:styled-content>\n 2<\/jats:sub>\n \u2010\n VAS<\/jats:styled-content>\n c score (\n P<\/jats:italic>\n =0.155). Median follow\u2010up was 3.4\u00a0years (interquartile range 1.5\u20136.5 years). Patients with familial\n AF<\/jats:styled-content>\n had risk of death and thromboembolism similar to those with nonfamilial\n AF<\/jats:styled-content>\n (adjusted hazard ratio 0.91 [95% CI 0.79\u20131.04] for death and 0.90 [95%\n CI<\/jats:styled-content>\n 0.71\u20131.14] for thromboembolism).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Although family history of\n AF<\/jats:styled-content>\n is associated with increased likelihood for development of\n AF<\/jats:styled-content>\n , once\n AF<\/jats:styled-content>\n developed, long\u2010term risks of death and thromboembolic complications were similar in familial and nonfamilial\n AF<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.003836","type":"journal-article","created":{"date-parts":[[2016,11,20]],"date-time":"2016-11-20T01:20:15Z","timestamp":1479604815000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Outcomes Associated With Familial Versus Nonfamilial Atrial Fibrillation: A Matched Nationwide Cohort Study"],"prefix":"10.1161","volume":"5","author":[{"given":"Anna","family":"Gundlund","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Herlev\u2010Gentofte, Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas Bjerring","family":"Olesen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Herlev\u2010Gentofte, Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Staerk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Herlev\u2010Gentofte, Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Herlev\u2010Gentofte, Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan P.","family":"Piccini","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric D.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Copenhagen, Rigshospitalet, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Torp\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar H.","family":"Gislason","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Herlev\u2010Gentofte, Hellerup, Denmark"},{"name":"The Danish Heart Foundation, Copenhagen, Denmark"},{"name":"The National Institute of Public Health, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil Loldrup","family":"Fosb\u00f8l","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Herlev\u2010Gentofte, Hellerup, Denmark"},{"name":"Department of Cardiology, University Hospital of Copenhagen, Rigshospitalet, Denmark"},{"name":"The Danish Heart Foundation, Copenhagen, 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