{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:32:39Z","timestamp":1790775159335,"version":"4.1.0"},"reference-count":67,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,10,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Overactivation of the aldosterone and mineralocorticoid receptor (\n              <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n              ) pathway is associated with hyperglycemia and dyslipidemia. Caveolin 1 (cav\u20101) is involved in glucose\/lipid homeostasis and may modulate\n              <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n              signaling. We investigated the interplay between cav\u20101 and aldosterone signaling in modulating insulin resistance and dyslipidemia in cav\u20101\u2013null mice and humans with a prevalent variant in the\n              <jats:italic>\n                <jats:styled-content style=\"fixed-case\">CAV<\/jats:styled-content>\n                1\n              <\/jats:italic>\n              gene.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In mouse studies, cav\u20101 knockout mice exhibited higher levels of homeostatic model assessment of insulin resistance, cholesterol, and resistin and lower ratios of high\u2010 to low\u2010density lipoprotein (all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 versus wild type). Moreover, cav\u20101 knockout mice displayed hypertriglyceridemia and higher\n              <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n              levels for resistin, retinol binding protein 4,\n              <jats:styled-content style=\"fixed-case\">NADPH<\/jats:styled-content>\n              oxidase 4, and aldose reductase in liver and\/or fat tissues.\n              <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n              blockade with eplerenone significantly decreased glycemia (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01), total cholesterol (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05), resistin (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05), and described enzymes, with no effect on insulin or triglycerides. In the human study, we analyzed the\n              <jats:italic>\n                <jats:styled-content style=\"fixed-case\">CAV<\/jats:styled-content>\n                1\n              <\/jats:italic>\n              gene polymorphism rs926198 in 556 white participants; 58% were minor allele carriers and displayed higher odds of insulin resistance (odds ratio 2.26 [95% CI 1.40\u20133.64]) and low high\u2010density lipoprotein (odds ratio 1.54 [95% CI 1.01\u20133.37]). Aldosterone levels correlated with higher homeostatic model assessment of insulin resistance and resistin and lower high\u2010density lipoprotein only in minor allele carriers.\n              <jats:italic>\n                <jats:styled-content style=\"fixed-case\">CAV<\/jats:styled-content>\n                1\n              <\/jats:italic>\n              gene expression quantitative trait loci data revealed lower cav\u20101 expression in adipose tissues by the rs926198 minor allele.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Our findings in mice and humans suggested that decreased cav\u20101 expression may activate the effect of aldosterone\/\n              <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n              signaling on several pathways of glycemia, dyslipidemia, and resistin. In contrast, hyperinsulinemia and hypertriglyceridemia are likely mediated by\n              <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n              \u2010independent mechanisms. Future human studies will elucidate the clinical relevance of\n              <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n              blockade in patients with genotype\u2010mediated cav\u20101 deficiency.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.003845","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T03:48:59Z","timestamp":1475120939000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Caveolin 1 Modulates Aldosterone\u2010Mediated Pathways of Glucose and Lipid Homeostasis"],"prefix":"10.1161","volume":"5","author":[{"given":"Rene","family":"Baudrand","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"},{"name":"Department of Endocrinology, School of Medicine, Pontificia Universidad Catolica De Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda E.","family":"Garza","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Vaidya","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A.","family":"Leopold","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul N.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Cardiovascular Genetics, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Jeunemaitre","sequence":"additional","affiliation":[{"name":"Centre d'Investigation Clinique Inserm\/AP, Departement de Genetique, H\u020fpital European Georges Pompidou, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Ferri","sequence":"additional","affiliation":[{"name":"Department MeSVA, San Salvatore Hospital, University of L'Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose R.","family":"Romero","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Loscalzo","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail K.","family":"Adler","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon H.","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luminita H.","family":"Pojoga","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2012.27"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-008-0009-y"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1733"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.112.194787"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.748640"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp191"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030207"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-012-0323-2"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.51.243"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.02.012"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2738"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.09.005"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2012.07.013"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00006.2003"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110970200"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00380.2010"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-10-0458"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01014.2007"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00661.2009"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0514"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00676.2007"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0893fje"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.111.00662"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002003"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612819666131206103102"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.06193-11"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.5.1844-1854.2004"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000211738.63207.c3"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.5.1092"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-136572"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.12.5146-5157.2005"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1545"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2521"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.02.005"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.110.159459"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnh.0000436543.48391.e0"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.708537"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/906327"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-1222-9_4"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2006.11.011"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2007.04.001"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.01.004"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2011.12.002"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.02.065"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0869"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e3283533955"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2814-8"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.113.209189"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2013.05.002"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800070-JLR200"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054862"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03711"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1520"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.205"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.8.1937"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2204"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328332b778"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00087"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1177\/1470320310391330"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-1691"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1515\/bmc.2011.002"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.107.151852"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.11.11848"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.06.028"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn080"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1017"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000056744.26901.ba"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.116.003845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:12:32Z","timestamp":1715595152000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.116.003845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,3]]},"references-count":67,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10,3]]}},"alternative-id":["10.1161\/JAHA.116.003845"],"URL":"https:\/\/doi.org\/10.1161\/jaha.116.003845","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,3]]},"assertion":[{"value":"2016-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e003845"}}