{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:41:47Z","timestamp":1765356107623,"version":"3.41.2"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,10,3]]},"abstract":"\n Background<\/jats:title>\n \n Speckle tracking echocardiography (\n STE<\/jats:styled-content>\n ) is reported as a useful method to predict cardiac resynchronization therapy (\n CRT<\/jats:styled-content>\n ) responders. This study aimed to identify the incremental value of a\n STE<\/jats:styled-content>\n parameter to predict\n CRT<\/jats:styled-content>\n responders.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We enrolled 171 patients from the Speckle Tracking imaging for the Assessment of cardiac Resynchronization Therapy (\n START<\/jats:styled-content>\n ) study.\n CRT<\/jats:styled-content>\n responders were defined as patients with \u226515% reduction of left ventricular (\n LV<\/jats:styled-content>\n ) end\u2010systolic volume at 6\u00a0months post\u2010\n CRT<\/jats:styled-content>\n . Based on multivariable logistic regression analysis, incremental values of\n STE<\/jats:styled-content>\n were assessed by c\u2010statistics, net reclassification improvement (\n NRI<\/jats:styled-content>\n )\/integrated discrimination improvement (\n IDI<\/jats:styled-content>\n ), and decision curve analysis. Six parameters (left bundle branch block or right ventricular pacing, use of beta\u2010blocker, blood urea nitrogen \u22643.0\u00a0mg\/dL,\n LV<\/jats:styled-content>\n end\u2010systolic diameter \u226450\u00a0mm, mitral regurgitation index \u226440%, and\n STE<\/jats:styled-content>\n parameter standard deviation of time from QRS onset to first peak on the circumferential strain curves [\n \n T\n SD<\/jats:sub>\n <\/jats:styled-content>\n ] \u2265116\u00a0ms) were identified as the determinants. Compared to the multivariable logistic regression model without\n \n T\n SD<\/jats:sub>\n <\/jats:styled-content>\n (model 1), that with\n \n T\n SD<\/jats:sub>\n <\/jats:styled-content>\n (model 2) showed significant improvement to predict\n CRT<\/jats:styled-content>\n responders: c\u2010statistic (0.86 vs 0.77;\n P<\/jats:italic>\n <0.001),\n NRI<\/jats:styled-content>\n =0.19,\n P<\/jats:italic>\n <0.001, and\n IDI<\/jats:styled-content>\n =0.17,\n P<\/jats:italic>\n <0.001. The decision curve of model 2 was higher than that of model 1 at threshold probabilities \u22650.2. Based on model 2, a\n START<\/jats:styled-content>\n score was constructed. Compared to the Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (\n MADIT<\/jats:styled-content>\n \u2010\n CRT<\/jats:styled-content>\n ) score, the decision curve of the\n START<\/jats:styled-content>\n score was higher than that of the\n MADIT<\/jats:styled-content>\n \u2010\n CRT<\/jats:styled-content>\n score at threshold probabilities \u22650.2.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Based on various statistical methods, this study revealed that\n STE<\/jats:styled-content>\n had an incremental value to predict\n CRT<\/jats:styled-content>\n responders.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.003882","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T03:44:59Z","timestamp":1476935099000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Incremental Value of Speckle Tracking Echocardiography to Predict Cardiac Resynchronization Therapy (CRT) Responders"],"prefix":"10.1161","volume":"5","author":[{"given":"Yoshihiro","family":"Seo","sequence":"first","affiliation":[{"name":"Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Ishizu","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Machino\u2010Ohtsuka","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Machino","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kuroki","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiro","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Nogami","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Aonuma","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906431"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.743120"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-0861"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq213"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.12.030"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-14-0842"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2012.182550"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2929"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181c30fb2"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X06295361"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-007049"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.17942"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.01.003"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.014324"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12574-014-0234-0"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.000026"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.107.746933"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.01.052"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908193410806"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105313442201"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.10.1295"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.000797"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.116.003882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:12:05Z","timestamp":1715595125000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.116.003882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,3]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10,3]]}},"alternative-id":["10.1161\/JAHA.116.003882"],"URL":"https:\/\/doi.org\/10.1161\/jaha.116.003882","relation":{},"ISSN":["2047-9980"],"issn-type":[{"type":"electronic","value":"2047-9980"}],"subject":[],"published":{"date-parts":[[2016,10,3]]},"assertion":[{"value":"2016-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e003882"}}