{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:05:07Z","timestamp":1791475507876,"version":"4.3.4"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,10,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Remote ischemic preconditioning (\n              <jats:styled-content style=\"fixed-case\">RIPC<\/jats:styled-content>\n              ) has been shown to reduce infarct size in animal models. We hypothesized that\n              <jats:styled-content style=\"fixed-case\">RIPC<\/jats:styled-content>\n              before an elective vascular operation would reduce the incidence and amount of a postoperative rise of the cardiac troponin level.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Cardiac Remote Ischemic Preconditioning Prior to Elective Vascular Surgery (\n              <jats:styled-content style=\"fixed-case\">CRIPES<\/jats:styled-content>\n              ) was a prospective, randomized, sham\u2010controlled phase 2 trial using\n              <jats:styled-content style=\"fixed-case\">RIPC<\/jats:styled-content>\n              before elective vascular procedures. The\n              <jats:styled-content style=\"fixed-case\">RIPC<\/jats:styled-content>\n              protocol consisted of 3 cycles of 5\u2010minute forearm ischemia followed by 5 minutes of reperfusion. The primary endpoint was the proportion of subjects with a detectable increase in cardiac troponin I (\n              <jats:styled-content style=\"fixed-case\">cTnI<\/jats:styled-content>\n              ) and the distribution of such increases. From June 2011 to September 2015, 201 male patients (69\u00b17, years) were randomized to either\n              <jats:styled-content style=\"fixed-case\">RIPC<\/jats:styled-content>\n              (n=100) or a sham procedure (n=101). Indications for vascular surgery included an expanding abdominal aortic aneurysm (n=115), occlusive peripheral arterial disease of the lower extremities (n=37), or internal carotid artery stenosis (n=49). Of the 201 patients, 47 (23.5%) had an increase in\n              <jats:styled-content style=\"fixed-case\">cTnI<\/jats:styled-content>\n              above the upper reference limit within 72\u00a0hours of the vascular operation, with no statistically significant difference between those patients assigned to\n              <jats:styled-content style=\"fixed-case\">RIPC<\/jats:styled-content>\n              (n=22; 22.2%) versus sham procedure (n=25; 24.7%;\n              <jats:italic>P<\/jats:italic>\n              =0.67). Among the cohort with increased\n              <jats:styled-content style=\"fixed-case\">cTnI<\/jats:styled-content>\n              , the median peak values (interquartile range) in the\n              <jats:styled-content style=\"fixed-case\">RIPC<\/jats:styled-content>\n              and control group were 0.048 (0.004\u20130.174) and 0.017 (0.003\u20130.105), respectively (\n              <jats:italic>P<\/jats:italic>\n              =0.54).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In this randomized, controlled trial of men with increased perioperative cardiac risks, elevation in cardiac troponins was common following vascular surgery, but was not reduced by a strategy of\n              <jats:styled-content style=\"fixed-case\">RIPC<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n              :\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier:\n              <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n              01558596.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.003916","type":"journal-article","created":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T01:20:10Z","timestamp":1475198410000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["<i>C<\/i>\n            ardiac\n            <i>R<\/i>\n            emote\n            <i>I<\/i>\n            schemic\n            <i>P<\/i>\n            reconditioning Prior to\n            <i>E<\/i>\n            lective Vascular\n            <i>S<\/i>\n            urgery (CRIPES): A Prospective, Randomized, Sham\u2010Controlled Phase\u00a0II Clinical Trial"],"prefix":"10.1161","volume":"5","author":[{"given":"Santiago","family":"Garcia","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Minneapolis VA Healthcare System, Minneapolis, MN"},{"name":"Division of Cardiology, University of Minnesota, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Rector","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Minneapolis VA Healthcare System, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Zakharova","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Minnesota, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah R.","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Minneapolis VA Healthcare System, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selcuk","family":"Adabag","sequence":"additional","affiliation":[{"name":"Division of Cardiology, 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MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil S.","family":"Brilakis","sequence":"additional","affiliation":[{"name":"VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward O.","family":"McFalls","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Minneapolis VA Healthcare System, Minneapolis, MN"},{"name":"Division of Cardiology, University of Minnesota, Minneapolis, 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