{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T12:32:33Z","timestamp":1769949153441,"version":"3.49.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,8,8]]},"abstract":"\n Background<\/jats:title>\n \n The impact of different combinations of glucose tolerance and blood pressure status on the development of type 2 diabetes mellitus (T2\n DM<\/jats:styled-content>\n ), hypertension (\n HTN<\/jats:styled-content>\n ), and chronic kidney disease (\n CKD<\/jats:styled-content>\n ) still needs to be investigated.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n A total of 12\u00a0808 Iranian adults aged \u226520\u00a0years were included in 3 separate analyses to investigate incidence of T2\n DM<\/jats:styled-content>\n ,\n HTN<\/jats:styled-content>\n , and\n CKD<\/jats:styled-content>\n . Multivariate Cox proportional hazard models were used to calculate hazard ratios (95%\n CI<\/jats:styled-content>\n ). During a median follow\u2010up of >10\u00a0years, the overall incidence rate for T2\n DM<\/jats:styled-content>\n ,\n HTN<\/jats:styled-content>\n , and\n CKD<\/jats:styled-content>\n was 12.2, 29.8, and 24.8 per 1000\u00a0person\u2010years. For incident T2\n DM<\/jats:styled-content>\n , considering normal glucose tolerance\/normal blood pressure as reference, prediabetes (Pre\n DM<\/jats:styled-content>\n )\/\n HTN<\/jats:styled-content>\n had the highest risk (hazard ratio: 7.22 [5.71\u20139.12]) while Pre\n DM<\/jats:styled-content>\n \/normal blood pressure also showed a significant risk (5.58 [4.41\u20137.05]). Furthermore, risk of Pre\n DM<\/jats:styled-content>\n \/\n HTN<\/jats:styled-content>\n was higher than Pre\n DM<\/jats:styled-content>\n \/normal blood pressure (\n P<\/jats:italic>\n <0.05). For incident\n HTN<\/jats:styled-content>\n , normal glucose tolerance\/prehypertension was a strong predictor (3.28 [2.91\u20133.69]); however, addition of Pre\n DM<\/jats:styled-content>\n or T2\n DM<\/jats:styled-content>\n did not increase the risk. For incident\n CKD<\/jats:styled-content>\n , every category that included\n HTN<\/jats:styled-content>\n and\/or T2\n DM<\/jats:styled-content>\n showed significant risk; this risk was marginally significant for the Pre\n DM<\/jats:styled-content>\n \/\n HTN<\/jats:styled-content>\n group (1.19 [0.98\u20131.43],\n P<\/jats:italic>\n =0.06). In addition, Pre\n DM<\/jats:styled-content>\n \/ normal blood pressure was a marginally significant risk factor for incident\n HTN<\/jats:styled-content>\n while normal glucose tolerance\/prehypertension was a significant predictor of T2\n DM<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Presence of\n HTN<\/jats:styled-content>\n was associated with increased risk of T2\n DM<\/jats:styled-content>\n among the Pre\n DM<\/jats:styled-content>\n population; however, dysglycemia did not increase the risk of\n HTN<\/jats:styled-content>\n among individuals with prehypertension. For incident\n CKD<\/jats:styled-content>\n , intensive management of\n HTN<\/jats:styled-content>\n and T2\n DM<\/jats:styled-content>\n , rather than their predisease states, should be considered.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.003917","type":"journal-article","created":{"date-parts":[[2016,8,21]],"date-time":"2016-08-21T00:28:18Z","timestamp":1471739298000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Different Combinations of Glucose Tolerance and Blood Pressure Status and Incident Diabetes, Hypertension, and Chronic Kidney Disease"],"prefix":"10.1161","volume":"5","author":[{"given":"Arash","family":"Derakhshan","sequence":"first","affiliation":[{"name":"Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 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