{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T06:39:32Z","timestamp":1771569572479,"version":"3.50.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,10,26]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Smad nuclear interacting protein 1 (\n              <jats:styled-content style=\"fixed-case\">SNIP<\/jats:styled-content>\n              1) plays a critical role in cell proliferation, transformation of embryonic fibroblasts, and immune regulation. However, the role of\n              <jats:styled-content style=\"fixed-case\">SNIP<\/jats:styled-content>\n              1 in cardiac hypertrophy remains unclear.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Here we examined the role of\n              <jats:styled-content style=\"fixed-case\">SNIP<\/jats:styled-content>\n              1 in pressure overload\u2013induced cardiac hypertrophy and its mechanisms. Our results demonstrated that\n              <jats:styled-content style=\"fixed-case\">SNIP<\/jats:styled-content>\n              1 expression was downregulated in human dilated cardiomyopathic hearts, aortic banding\u2010induced mice hearts, and angiotensin\n              <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n              \u2013treated cardiomyocytes. Accordingly,\n              <jats:styled-content style=\"fixed-case\">SNIP<\/jats:styled-content>\n              1 deficiency significantly exacerbated aortic banding\u2013induced cardiac hypertrophy, fibrosis, and contractile dysfunction, whereas cardiac\u2010specific overexpression of\n              <jats:styled-content style=\"fixed-case\">SNIP<\/jats:styled-content>\n              1 markedly recovered pressure overload\u2013induced cardiac hypertrophy and fibrosis. Besides that,\n              <jats:styled-content style=\"fixed-case\">SNIP<\/jats:styled-content>\n              1 protected neonatal rat cardiomyocytes against angiotensin\n              <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n              \u2013induced hypertrophy in\u00a0vitro. Moreover, we identified that\n              <jats:styled-content style=\"fixed-case\">SNIP<\/jats:styled-content>\n              1 suppressed nuclear factor\u2010\u03baB signaling during pathological cardiac hypertrophy, and inhibition of nuclear factor\u2010\u03baB signaling by a cardiac\u2010specific conditional inhibitor of \u03ba\n              <jats:styled-content style=\"fixed-case\">\n                B\n                <jats:sup>S<\/jats:sup>\n              <\/jats:styled-content>\n              <jats:sup>32A\/S36A<\/jats:sup>\n              transgene blocked these adverse effects of\n              <jats:styled-content style=\"fixed-case\">SNIP<\/jats:styled-content>\n              1 deficiency on hearts.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Together, our findings demonstrated that\n              <jats:styled-content style=\"fixed-case\">SNIP<\/jats:styled-content>\n              1 had protective effects in pressure overload\u2013induced pathological cardiac hypertrophy via inhibition of nuclear factor\u2010\u03baB signaling. Thus,\n              <jats:styled-content style=\"fixed-case\">SNIP<\/jats:styled-content>\n              1 may be a novel approach for the treatment of heart failure.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.003943","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T02:40:19Z","timestamp":1477536019000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Smad Nuclear Interacting Protein 1 Acts as a Protective Regulator of Pressure Overload\u2010Induced Pathological Cardiac Hypertrophy"],"prefix":"10.1161","volume":"5","author":[{"given":"Yu\u2010yan","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cardiovascular Disease Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da\u2010chun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Disease Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010fan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Disease Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo\u2010fu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Disease Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng\u2010yun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Disease Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Disease Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue\u2010jing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Disease Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Disease Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Disease Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Disease Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06254"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.11.009"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02313"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.10.020"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05469"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1983"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.02.010"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305230"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81573-1"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000072977.86706.23"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02653"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.226928"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.13.1605"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208025"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.11.006"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103819200"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4303"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.260729"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001297"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00428.2011"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22623"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.07.006"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1116584109"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000164237.58200.5A"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.193318"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.202200"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.116.003943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:21:31Z","timestamp":1715595691000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.116.003943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,26]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,10,26]]}},"alternative-id":["10.1161\/JAHA.116.003943"],"URL":"https:\/\/doi.org\/10.1161\/jaha.116.003943","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,26]]},"assertion":[{"value":"2016-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e003943"}}