{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:09:23Z","timestamp":1767773363831,"version":"3.41.2"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,10,26]]},"abstract":"\n Background<\/jats:title>\n \n Drug\u2010eluting stents (\n DES<\/jats:styled-content>\n s) and bare metal stents (\n BMS<\/jats:styled-content>\n s) are both recommended to improve coronary revascularization and to treat coronary artery disease in patients with chronic kidney disease (\n CKD<\/jats:styled-content>\n ). However, the potential superiority of\n DES<\/jats:styled-content>\n s over\n BMS<\/jats:styled-content>\n s for reducing the incidence of long\u2010term major adverse cardiovascular events and mortality in\n CKD<\/jats:styled-content>\n patients has not been established, and the results remain controversial. We aimed to systematically assess and quantify the total weight of evidence regarding the use of\n DES<\/jats:styled-content>\n s versus\n BMS<\/jats:styled-content>\n s in\n CKD<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n In this systematic review and\u00a0conventional meta\u2010analysis, electronic studies published in any language until May 20, 2016, were systematically searched through PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials. We included randomized controlled trials and observational studies comparing outcomes in\n CKD<\/jats:styled-content>\n patients with\n DES<\/jats:styled-content>\n s versus\n BMS<\/jats:styled-content>\n s and extracted data in a standard form. Pooled odd ratios and 95% CIs were calculated using random\u2010 and fixed\u2010effects models. Finally, 38 studies involving 123\u00a0396 patients were included. The use of\n DES<\/jats:styled-content>\n s versus\n BMS<\/jats:styled-content>\n s was associated with significant reductions in major adverse cardiovascular events (pooled odds ratio 0.75; 95%\n CI<\/jats:styled-content>\n , 0.64\u20130.88;\n P<\/jats:italic>\n <0.001), all\u2010cause mortality (odds ratio 0.81; 95%\n CI<\/jats:styled-content>\n , 0.73\u20130.90;\n P<\/jats:italic>\n <0.001), myocardial infarction, target\u2010lesion revascularization, and target\u2010vessel revascularization. The superiority of\n DES<\/jats:styled-content>\n s over\n BMS<\/jats:styled-content>\n s for improving clinical outcomes was attenuated in randomized controlled trials.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The use of\n DES<\/jats:styled-content>\n s significantly improves the above outcomes in\n CKD<\/jats:styled-content>\n patients. Nevertheless, large\u2010sized randomized controlled trials are necessary to determine the real effect on\n CKD<\/jats:styled-content>\n patients and whether efficacy differs by type of\n DES<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.003990","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T03:43:49Z","timestamp":1478576629000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Comparison of Drug\u2010Eluting and Bare Metal Stents in Patients With Chronic Kidney Disease: An Updated Systematic Review and Meta\u2010Analysis"],"prefix":"10.1161","volume":"5","author":[{"given":"Renjie","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The Third People's Hospital of Changzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenglei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Third People's Hospital of Changzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The Third People's Hospital of Changzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xishan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urinary Surgery, The Third People's Hospital of Changzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanmei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Third People's Hospital of Changzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganlin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urinary Surgery, The Third People's Hospital of Changzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinfeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Urinary Surgery, The Third People's Hospital of Changzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengda","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Third People's Hospital of Changzhou, Jiangsu, 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