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We undertake a systematic review and meta\u2010analysis of prospective studies to determine the effect of\n              <jats:styled-content style=\"fixed-case\">SGLT<\/jats:styled-content>\n              2 on blood pressure (BP) among individuals with type 2 diabetes mellitus.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              PubMed\u2010Medline, Web of Science, Cochrane Database, and Google Scholar databases were searched to identify trial registries evaluating the impact of\n              <jats:styled-content style=\"fixed-case\">SGLT<\/jats:styled-content>\n              2 on BP. Random\u2010effects models meta\u2010analysis was used for quantitative data\u00a0synthesis. The meta\u2010analysis indicated a significant reduction in systolic BP following treatment with\n              <jats:styled-content style=\"fixed-case\">SGLT<\/jats:styled-content>\n              2 (weighted mean difference \u22122.46\u00a0mm\u00a0Hg [95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              \u22122.86 to \u22122.06]). The weighted mean differences for the effect on diastolic BP was \u22121.46\u00a0mm\u00a0Hg (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              \u00a0\u22121.82 to \u22121.09). In these subjects the weighted mean difference effects on serum triglycerides and total cholesterol were \u22122.08\u00a0mg\/dL (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              \u22122.51 to \u22121.64) and 0.77\u00a0mg\/dL (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.33\u20101.21), respectively. The weighted mean differences for the effect of\n              <jats:styled-content style=\"fixed-case\">SGLT<\/jats:styled-content>\n              2 on body weight was \u22121.88\u00a0kg (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              \u22122.11 to \u22121.66) across all studies. These findings were robust in sensitivity analyses.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Treatment with\n              <jats:styled-content style=\"fixed-case\">SGLT<\/jats:styled-content>\n              2 glucose cotransporter inhibitors therefore has beneficial off\u2010target effects on BP in patients with type 2 diabetes mellitus and may also be of value in improving other cardiometabolic parameters including lipid profile and body weight in addition to their expected effects on glycemic control. However, our findings should be interpreted with consideration for the moderate statistical heterogeneity across the included studies.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.004007","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T00:20:10Z","timestamp":1495758010000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":291,"title":["Effect of Sodium\u2010Glucose Cotransport\u20102 Inhibitors on Blood Pressure in People With Type 2 Diabetes Mellitus: A Systematic Review and Meta\u2010Analysis of 43 Randomized Control Trials With 22 528 Patients"],"prefix":"10.1161","volume":"6","author":[{"given":"Mohsen","family":"Mazidi","sequence":"first","affiliation":[{"name":"Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China"},{"name":"Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Science, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyman","family":"Rezaie","sequence":"additional","affiliation":[{"name":"Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Kai","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The General Hospital of Chinese People's Armed Police Forces, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre Pascal","family":"Kengne","sequence":"additional","affiliation":[{"name":"Non\u2010Communicable Disease Research Unit, South African Medical Research Council and University of Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2016.92"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-9917"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706245"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2003.12.002"},{"key":"e_1_3_4_6_2","first-page":"77","article-title":"Treatment with GLP1 receptor agonists reduce serum CRP concentrations in patients with type 2 diabetes mellitus: a systematic review and meta\u2010analysis of randomized controlled trials","volume":"8","author":"Mazidi M","year":"2016","unstructured":"Mazidi M, Karimi E, Rezaie P, Ferns GA. 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