{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:38:52Z","timestamp":1793137132721,"version":"4.5.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,8,8]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The risk of aortic complications associated with pregnancy in women with Marfan syndrome (\n                      <jats:styled-content style=\"fixed-case\">MFS<\/jats:styled-content>\n                      ) is not fully understood.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      <jats:styled-content style=\"fixed-case\">MFS<\/jats:styled-content>\n                      women participating in the large National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (Gen\n                      <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>\n                      ) were evaluated. Among 184 women with\n                      <jats:styled-content style=\"fixed-case\">MFS<\/jats:styled-content>\n                      in whom pregnancy information was available, 94 (51%) had a total of 227 pregnancies. Among the women with pregnancies, 10 (10.6%) experienced a pregnancy\u2010related aortic complication (4 type A and 3 type B dissections, 1 coronary artery dissection, and 2 with significant [\u22653\u00a0mm] aortic growth). Five of 7 aortic dissections, including all 3 type B, and the coronary dissection (75% of all dissections) occurred in the postpartum period. Only 5 of 8 women with pregnancy\u2010associated dissection were aware of their\n                      <jats:styled-content style=\"fixed-case\">MFS<\/jats:styled-content>\n                      diagnosis. The rate of aortic dissection was higher during the pregnancy and postpartum period (5.4 per 100\u00a0person\u2010years vs 0.6 per 100\u00a0person\u2010years of nonpregnancy; rate ratio, 8.4 [95% CI=3.9, 18.4];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Pregnancy in\n                      <jats:styled-content style=\"fixed-case\">MFS<\/jats:styled-content>\n                      is associated with an increased risk of aortic dissection, both types A and B, particularly in the immediate postpartum period. Lack of knowledge of underlying\n                      <jats:styled-content style=\"fixed-case\">MFS<\/jats:styled-content>\n                      diagnosis before aortic dissection is a major contributing factor. These findings underscore the need for early diagnosis, prepregnancy risk counseling, and multidisciplinary peripartum management.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.116.004052","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T22:28:48Z","timestamp":1470954528000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":91,"title":["Aortic Complications Associated With Pregnancy in Marfan Syndrome: The NHLBI National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC)"],"prefix":"10.1161","volume":"5","author":[{"given":"Mary J.","family":"Roman","sequence":"first","affiliation":[{"name":"Division of Cardiology, Weill Cornell Medical College, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma L.","family":"Pugh","sequence":"additional","affiliation":[{"name":"Biostatistics and Epidemiology Division, RTI International, Rockville, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabitha P.","family":"Hendershot","sequence":"additional","affiliation":[{"name":"Biostatistics and Epidemiology Division, RTI International, Rockville, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Devereux","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Weill Cornell Medical College, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hal","family":"Dietz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oregon Health &amp; Sciences University, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim A.","family":"Eagle","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Michigan Health System, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"LeMaire","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianna M.","family":"Milewicz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaine A.","family":"Morris","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reed E.","family":"Pyeritz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Ravekes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph V.","family":"Shohet","sequence":"additional","affiliation":[{"name":"Department of Medicine, John A. Burns School of Medicine, Honolulu, HI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Silberbach","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oregon Health &amp; Sciences University, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry C.","family":"Dietz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Habashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth K.","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl L.","family":"Maslen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard K.","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Bavaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karianna","family":"Milewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Weinsaft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazli","family":"McDonnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico M.","family":"Asch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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