{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:11:54Z","timestamp":1790953914314,"version":"4.1.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,9]]},"abstract":"\n Background<\/jats:title>\n \n Alcohol consumption has been associated with atrial fibrillation (\n AF<\/jats:styled-content>\n ) in several epidemiologic studies, but the underlying mechanisms remain unknown. We sought to test the hypothesis that an atrial myopathy, manifested by echocardiographic left atrial enlargement, explains the association between chronic alcohol use and\n AF<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We evaluated the relationship between cumulative alcohol consumption and risk of incident\n AF<\/jats:styled-content>\n in 5220 Offspring and Original Framingham Heart Study participants (mean age 56.3\u00a0years, 54% women) with echocardiographic left atrial size measurements. The incidence of\n AF<\/jats:styled-content>\n was 8.4 per 1000\u00a0person\u2010years, with 1088 incident\n AF<\/jats:styled-content>\n cases occurring over a median 6.0 years (25th\u201375th percentiles 4.0\u20138.7\u00a0years) of follow\u2010up. After multivariable adjustment for potential confounders, every additional 10\u00a0g of alcohol per day (just under 1\u00a0drink per day) was associated with a 0.16\u00a0mm (95%\n CI<\/jats:styled-content>\n , 0.10\u20130.21\u00a0mm) larger left atrial dimension. Also in multivariable adjusted analysis, every 10\u00a0g per day of alcohol consumed was associated with a 5% higher risk of developing new\u2010onset\n AF<\/jats:styled-content>\n (hazard ratio, 1.05; 95%\n CI<\/jats:styled-content>\n , 1.01\u20131.09). An estimated 24% (95%\n CI<\/jats:styled-content>\n , 8\u201375) of the association between alcohol and\n AF<\/jats:styled-content>\n risk was explained by left atrial enlargement.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Our study of a large, community\u2010based sample identified alcohol consumption as a predictor of left atrial enlargement and subsequent incident\n AF<\/jats:styled-content>\n . Left atrial enlargement may be an intermediate phenotype along the causal pathway linking long\u2010term alcohol consumption to\n AF<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.004060","type":"journal-article","created":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T02:29:06Z","timestamp":1473906546000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":106,"title":["Alcohol Consumption, Left Atrial Diameter, and Atrial Fibrillation"],"prefix":"10.1161","volume":"5","author":[{"given":"David D.","family":"McManus","sequence":"first","affiliation":[{"name":"Framingham Heart Study, Framingham, MA"},{"name":"Cardiovascular Medicine Division, Departments of Quantitative Health Sciences and Medicine, University of Massachusetts Medical School, Worcester, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Yin","sequence":"additional","affiliation":[{"name":"Framingham Heart Study, Framingham, MA"},{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Gladstone","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, University of California at San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Vittinghoff","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Epidemiology and Biostatistics, University of California at San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramachandran S.","family":"Vasan","sequence":"additional","affiliation":[{"name":"Framingham Heart Study, Framingham, MA"},{"name":"Preventive Medicine and Cardiology Sections, Boston University School of Medicine, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin G.","family":"Larson","sequence":"additional","affiliation":[{"name":"Framingham Heart Study, Framingham, MA"},{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelia J.","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Framingham Heart Study, Framingham, MA"},{"name":"Department of Epidemiology, Boston University School of Public Health, Boston, MA"},{"name":"Preventive Medicine and Cardiology Sections, Boston University School of Medicine, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Marcus","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, University of California at San Francisco, 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