{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:54:32Z","timestamp":1790250872633,"version":"4.1.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,10,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The extent to which angina is associated with future cardiovascular events in patients with coronary artery disease has long been debated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Included were outpatients with established coronary artery disease who were enrolled in the\n              <jats:styled-content style=\"fixed-case\">REACH<\/jats:styled-content>\n              registry and were followed for 4\u00a0years. Angina at baseline was defined as necessitating episodic or permanent antianginal treatment. The primary end point was the composite of cardiovascular death, myocardial infarction, or stroke. Secondary end points included heart failure, cardiovascular hospitalizations, and coronary revascularization. The independent association between angina and first\/total events was examined using Cox and logistic regression models. Out of 26\u00a0159 patients with established coronary artery disease, 13\u00a0619 (52%) had angina at baseline. Compared with patients without angina, patients with angina were more likely to be older, female, and had more heart failure and polyvascular disease (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 for each). Compared with patients without angina, patients with angina had higher rates of first primary end\u2010point event (14.2% versus 16.3%, unadjusted hazard ratio 1.19,\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.11\u20131.27,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; adjusted hazard ratio 1.06,\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.99\u20131.14,\n              <jats:italic>P<\/jats:italic>\n              =0.11), and total primary end\u2010point events (adjusted risk ratio 1.08,\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.01\u20131.16,\n              <jats:italic>P<\/jats:italic>\n              =0.03). Patients with angina were at increased risk for heart failure (adjusted odds ratio 1.17,\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.06\u20131.28,\n              <jats:italic>P<\/jats:italic>\n              =0.002), cardiovascular hospitalizations (adjusted odds ratio 1.29,\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.21\u20131.38,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and coronary revascularization (adjusted odds ratio 1.23,\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.13\u20131.34,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients with stable coronary artery disease and angina have higher rates of future cardiovascular events compared with patients without angina. After adjustment, angina was only weakly associated with cardiovascular death, myocardial infarction, or stroke, but significantly associated with heart failure, cardiovascular hospitalization, and coronary revascularization.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.004080","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T03:48:59Z","timestamp":1475120939000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":65,"title":["Angina and Future Cardiovascular Events in Stable Patients With Coronary Artery Disease: Insights From the Reduction of Atherothrombosis for Continued Health (REACH) Registry"],"prefix":"10.1161","volume":"5","author":[{"given":"Alon","family":"Eisen","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital, Boston, MA"},{"name":"Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak L.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Boston, MA"},{"name":"Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Gabriel","family":"Steg","sequence":"additional","affiliation":[{"name":"D\u00e9partement Hospitalo\u2010Universitaire FIRE (Fibrosis, Inflammation, Remodeling), Universit\u00e9 Paris\u2010Diderot, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"FACT (French Alliance for Cardiovascular Clinical Trials), H\u00f4pital Bichat, Assistance Publique\u2010H\u00f4pitaux de Paris, Paris, France"},{"name":"INSERM U\u20101148, Paris, France"},{"name":"National Heart and Lung Institute, Royal Brompton Hospital, Imperial College, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim A.","family":"Eagle","sequence":"additional","affiliation":[{"name":"University of Michigan Health System, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tokai University School of Medicine, Isehara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Guo","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Boston, MA"},{"name":"Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney C.","family":"Smith","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, University of North Carolina at Chapel Hill, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Magnus","family":"Ohman","sequence":"additional","affiliation":[{"name":"Duke University Medical Center, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin M.","family":"Scirica","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Boston, MA"},{"name":"Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the REACH Registry Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000350"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht296"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.08.013"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs289"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(81)90391-X"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.887380"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(03)00436-8"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.12.1404"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.3773"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.036"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415921"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.07.009"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070829"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.2.180"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.11.004"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1322"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.01.014"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.11.1197"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp355"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.12559"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(88)90160-X"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.13.1423"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.035"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00831-2"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.116.004080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:13:02Z","timestamp":1715595182000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.116.004080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,3]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10,3]]}},"alternative-id":["10.1161\/JAHA.116.004080"],"URL":"https:\/\/doi.org\/10.1161\/jaha.116.004080","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,3]]},"assertion":[{"value":"2016-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e004080"}}