{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:14:54Z","timestamp":1790644494465,"version":"4.1.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The prevalence of depression is 4\u2010 to 5\u2010fold higher in heart failure patients than in the general population. We examined the influence of depression on all\u2010cause mortality in patients with heart failure.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Using Danish medical registries, this nationwide population\u2010based cohort study included all patients with a first\u2010time hospitalization for heart failure (1995\u20132014). All\u2010cause mortality risks and 19\u2010year mortality rate ratios were estimated based on Cox regression analysis, adjusting for age, sex, time period, comorbidity, and socioeconomic status. The analysis included 9636 patients with and 194\u00a0887 patients without a diagnosis of depression. Compared with patients without a history of depression, those with depression had higher 1\u2010year (36% versus 33%) and 5\u2010year (68% versus 63%) mortality risks. Overall, the adjusted mortality rate ratio was 1.03 (95% CI 1.01\u20131.06). Compared with no depression, the adjusted mortality rate ratios for mild, moderate, and severe depression, as defined by diagnostic codes, were 1.06 (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.00\u20131.13), 1.03 (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.99\u20131.08), and 1.02 (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.96\u20131.09), respectively. In a subcohort of patients, the mortality rate ratios were modified by left ventricular ejection fraction, with adjusted mortality rate ratios of 1.17 (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 1.05\u20131.31) for \u226435%, 0.98 (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.81\u20131.18) for 36% to 49%, and 0.96 (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.74\u20131.25) for \u226550%. Results were consistent after adjustment for alcohol abuse and smoking.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">A history of depression was an adverse prognostic factor for all\u2010cause mortality in heart failure patients with left ventricular ejection fraction \u226435% but not for other heart failure patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.004137","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T02:38:21Z","timestamp":1473302301000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["Mortality Risk Among Heart Failure Patients With Depression: A Nationwide Population\u2010Based Cohort Study"],"prefix":"10.1161","volume":"5","author":[{"given":"Kasper","family":"Adelborg","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark"},{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark"},{"name":"Department of Medical Research, Odense University Hospital, Svendborg Hospital, Svendborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Sundb\u00f8ll","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark"},{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poul","family":"Videbech","sequence":"additional","affiliation":[{"name":"Mental Health Center Glostrup, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Erik","family":"B\u00f8tker","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Egstrup","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Odense University Hospital, Svendborg Hospital, Svendborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Toft","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.300268"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.06.055"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2003.09.008"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-008-9091-0"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2014.03.007"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2009.06.442"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01334-1"},{"key":"e_1_3_4_9_2","first-page":"CR643","article-title":"Depressive symptoms and mortality in patients with congestive heart failure: a six\u2010year follow\u2010up study","volume":"10","author":"Murberg TA","year":"2004","unstructured":"Murberg TA, Furze G. 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