{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T18:08:27Z","timestamp":1781806107799,"version":"3.54.5"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,10,26]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The evidence supporting the use of \u03b2\u2010blockers in patients with acute coronary syndrome after successful percutaneous coronary intervention has been inconsistent and scarce.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Between March 1, 2009, and December 30, 2014, a total of 3180 eligible patients with acute coronary syndrome undergoing percutaneous coronary intervention were consecutively enrolled. The primary end point was all\u2010cause death and the secondary end point was a composite of all\u2010cause death, nonfatal myocardial infarction, heart failure readmission, and cardiogenic hospitalization. Patients were compared according to the use of \u03b2\u2010blockers at discharge. Compared with the no \u03b2\u2010blocker group, the risk of all\u2010cause death was significantly lower in the \u03b2\u2010blocker group (hazard ratio [\n              <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n              ], 0.33; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 0.17\u20130.65 [\n              <jats:italic>P<\/jats:italic>\n              =0.001]). A consistent result was obtained in multiple adjusted model and propensity score\u2013matched analysis. The use of \u03b2\u2010blockers was also associated with decreased risk of composite of adverse cardiovascular events (\n              <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n              , 0.47; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 0.28\u20130.81 [\n              <jats:italic>P<\/jats:italic>\n              =0.006]), although statistical significance disappeared after multivariable adjustment and propensity score matching. Furthermore, we performed post hoc analysis for the subsets of patients and the results revealed that patients with non\u2013ST\u2010segment elevation myocardial infarction benefited the most from \u03b2\u2010blocker therapy at discharge (\n              <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n              , 0.04; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 0.00\u20130.27 [\n              <jats:italic>P<\/jats:italic>\n              =0.001]), and the use of &lt;50% of target dose was significantly associated with better outcome compared with no \u03b2\u2010blocker use, rather than \u226550% of target dose.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The administration of relatively low \u03b2\u2010blocker dose is associated with improved clinical outcomes among patients with acute coronary syndrome after successful percutaneous coronary intervention, especially for patients with non\u2010ST\u2010segment elevation myocardial infarction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.004190","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T03:55:23Z","timestamp":1479354923000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Relationship Between \u03b2\u2010Blocker Therapy at Discharge and Clinical Outcomes in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention"],"prefix":"10.1161","volume":"5","author":[{"given":"Chenze","family":"Li","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 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