{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:10:09Z","timestamp":1792383009853,"version":"4.4.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,10,3]]},"abstract":"\n Background<\/jats:title>\n \n Isolated nocturnal hypertension (\n INH<\/jats:styled-content>\n ) has been studied among the general population and hypertensive patients. However, little insight is available on the prognostic effect of\n INH<\/jats:styled-content>\n in patients with chronic kidney disease (\n CKD<\/jats:styled-content>\n ). This study investigated the prognostic effect of\n INH<\/jats:styled-content>\n in a cohort of Chinese patients with nondialysis\n CKD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n A total of 588 Chinese\n CKD<\/jats:styled-content>\n patients who were admitted to the Third Affiliated Hospital of Sun Yat\u2010Sen University were enrolled in this study. We monitored blood pressure (\n BP<\/jats:styled-content>\n ) throughout the day and followed health outcomes in the 588\n CKD<\/jats:styled-content>\n patients admitted to our hospital division. We recorded time to total mortality, cardiovascular mortality, renal events, and cardiovascular events. A total of 370 (62.92%) individuals had nocturnal hypertension, which included 136 (23.13%) patients with\n INH<\/jats:styled-content>\n . Multivariable Cox regression analyses showed that nocturnal\n BP<\/jats:styled-content>\n was a significant risk factor for renal events and cardiovascular events in\n CKD<\/jats:styled-content>\n patients, even when adjusted for clinic\n BP<\/jats:styled-content>\n , 24\u2010hour\n BP<\/jats:styled-content>\n , or daytime\n BP<\/jats:styled-content>\n . Patients with nocturnal hypertension showed a worse prognosis compared with patients with nocturnal normotension (\n P<\/jats:italic>\n <0.05), and nocturnal hypertension (versus nocturnal normotension) was associated with an increased risk for renal events (hazard ratio [\n HR<\/jats:styled-content>\n ], 3.81; 95%\n CI<\/jats:styled-content>\n , 1.74\u20138.36) and cardiovascular events (\n HR<\/jats:styled-content>\n , 8.34; 95%\n CI<\/jats:styled-content>\n , 1.98\u201335.07). In addition, patients with\n INH<\/jats:styled-content>\n had a worse prognosis than patients with normotension (\n P<\/jats:italic>\n <0.017), whereas\n INH<\/jats:styled-content>\n (versus normotension) was associated with a higher risk of renal events (\n HR<\/jats:styled-content>\n , 2.78; 95%\n CI<\/jats:styled-content>\n , 1.16\u20136.65) and cardiovascular events (\n HR<\/jats:styled-content>\n , 6.82; 95%\n CI<\/jats:styled-content>\n , 1.52\u201330.63).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n INH<\/jats:styled-content>\n was associated with a poor prognosis in Chinese nondialysis\n CKD<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.004198","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T17:19:54Z","timestamp":1476206394000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":42,"title":["Prognostic Effect of Isolated Nocturnal Hypertension in Chinese Patients With Nondialysis Chronic Kidney Disease"],"prefix":"10.1161","volume":"5","author":[{"given":"Cheng","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, First Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengchun","family":"Ye","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunzi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Ma","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Peng","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanqi","family":"Lou","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2010.02269.x"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60033-6"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70102-0"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.07.006"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005101085"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32833b49fe"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.133900"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2012.26"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.087767"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12589"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055419"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002025"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/08037051.2014.868629"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00217"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.243"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-S005"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11301111"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00804-4"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000100560.46946.EA"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08594-X"},{"key":"e_1_3_4_23_2","first-page":"1709","article-title":"Arterial blood pressure circadian rhythm: significance and clinical implications","volume":"8","author":"Gonzalez RE","year":"2012","unstructured":"Gonzalez RE, Hernandez A, Dibner C, Koehler BB, Pechere\u2010Bertschi A. Arterial blood pressure circadian rhythm: significance and clinical implications. Rev Med Suisse. 2012;8:1709\u20131712.","journal-title":"Rev Med Suisse"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft285"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12021"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.200477"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.116.004198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:10:59Z","timestamp":1715595059000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.116.004198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,3]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10,3]]}},"alternative-id":["10.1161\/JAHA.116.004198"],"URL":"https:\/\/doi.org\/10.1161\/jaha.116.004198","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,3]]},"assertion":[{"value":"2016-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e004198"}}