{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:22:01Z","timestamp":1790803321015,"version":"4.1.0"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,10,26]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      South Asians have a low body mass index and high prevalence of cardiovascular disease (\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      ) relative to other racial\/ethnic groups. Radiographically detected ectopic fat distribution is better associated with\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      than body mass index. We assessed whether differences in ectopic fat depots explained differences in the prevalence\/severity of coronary artery calcium (\n                      <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n                      ), a predictor of incident\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      events, among South Asians compared with other racial\/ethnic groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We examined the associations of radiographically detected visceral, intermuscular, intrahepatic, and pericardial fat with\n                      <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n                      among adults without baseline\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      . We compared 803 South Asians in the Mediators of Atherosclerosis in South Asians Living in America to 4 racial\/ethnic groups in the Multi\u2010Ethnic Study of Atherosclerosis: 2622 whites, 1893 blacks, 1496 Latinos, and 803 Chinese Americans. We adjusted for body mass index and known\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      risk factors. South Asians had the highest intrahepatic fat and lowest pericardial fat volume (\n                      <jats:styled-content style=\"fixed-case\">PFV<\/jats:styled-content>\n                      ). There was a positive graded association between ectopic fat and higher\n                      <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n                      scores in all the groups with the strongest associations observed with\n                      <jats:styled-content style=\"fixed-case\">PFV<\/jats:styled-content>\n                      .\n                      <jats:styled-content style=\"fixed-case\">PFV<\/jats:styled-content>\n                      was independently associated with\n                      <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n                      severity in South Asians (\n                      <jats:italic>P<\/jats:italic>\n                      =0.01) and blacks (\n                      <jats:italic>P<\/jats:italic>\n                      =0.05) and borderline in whites (\n                      <jats:italic>P<\/jats:italic>\n                      =0.06).\n                      <jats:styled-content style=\"fixed-case\">PFV<\/jats:styled-content>\n                      partially explained the higher\n                      <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n                      burden in South Asians compared with blacks, but not the other racial\/ethnic groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Differences in\n                      <jats:styled-content style=\"fixed-case\">PFV<\/jats:styled-content>\n                      explain a small fraction of the higher\n                      <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n                      burden in South Asians. Our findings suggest that ectopic fat depots may not explain the elevated\n                      <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n                      risk in South Asians.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.116.004257","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T22:15:21Z","timestamp":1479420921000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Ectopic Fat Depots and Coronary Artery Calcium in South Asians Compared With Other Racial\/Ethnic Groups"],"prefix":"10.1161","volume":"5","author":[{"given":"Sachin K.","family":"Garg","sequence":"first","affiliation":[{"name":"University of California San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"University of California San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namratha","family":"Kandula","sequence":"additional","affiliation":[{"name":"Northwestern University, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhong","family":"Ding","sequence":"additional","affiliation":[{"name":"Wake Forest University Medical Center, Winston\u2010Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Carr","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Allison","sequence":"additional","affiliation":[{"name":"University of California San Diego, San Diego, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Northwestern University, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Herrington","sequence":"additional","affiliation":[{"name":"Wake Forest University Medical Center, Winston\u2010Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhananjay","family":"Vaidya","sequence":"additional","affiliation":[{"name":"Johns Hopkins University, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Vittinghoff","sequence":"additional","affiliation":[{"name":"University of California San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alka M.","family":"Kanaya","sequence":"additional","affiliation":[{"name":"University of California San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","unstructured":"US Census Bureau . 2010 US Census\u2010demographic profile data. 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